Recombinant Rat Adenosine receptor A1(Adora1),partial

Code CSB-YP001375RA1
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Source Yeast
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Code CSB-EP001375RA1
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Source E.coli
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Code CSB-EP001375RA1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001375RA1
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Source Baculovirus
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Code CSB-MP001375RA1
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adora1
Uniprot No. P25099
Alternative Names Adora1Adenosine receptor A1
Species Rattus norvegicus (Rat)
Protein Length full length protein
Tag Info The following tags are available.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Gene References into Functions
  1. findings indicate that ADORA1 accelerated PC12 cells injury after intermittent hypoxia exposure via ADORA1/PKC/KATP signaling pathway. PMID: 29380238
  2. The article data suggest that 14 days under a 16:8 light-dark extended sleep photoperiod respectively down- and upregulated cortical adenosine AR and IGF-I levels in rats. PMID: 29149028
  3. Data suggested that adenosine A1 receptor might potentiate glycinergic transmission through Galphai/PKA/alpha3 and Gbetagamma/alpha1ins pathways in inflamed rat. PMID: 28882563
  4. This study demonstrated that Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain. PMID: 27792010
  5. that adenosine acting at A1 receptors negatively regulates adult neurogenesis while promoting astrogliogenesis PMID: 27301342
  6. activation of the A1 adenosine receptor by N(6)-cyclohexyladenosine could prevent intracerebral hemorrhage-induced secondary brain injury via the P38-MAPKAP2-Hsp27 pathway. PMID: 27301321
  7. Report down-regulation of pancreatic islet Adora1 expression in rat with ventromedial hypothalamic lesions. PMID: 26658041
  8. tonic activation of adenosine A1 receptors plays an important role in the reoxygenation recovery of the metabolic alterations caused by transient hypoxia in rat hippocampal slices PMID: 26709861
  9. Data suggest, in cardiac myoblasts, AdorA1 (A1 adenosine receptor) stimulation increases TG2 (transglutaminase 2) phosphorylation/activity via MAP kinase-/Ca2+-dependent signaling; substrate specificity of AdorA1 includes histone 4 and hexokinase 1. PMID: 27005940
  10. Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt and ERK1/2 phosphorylation via A1R-mediated transactivation of EGFR. PMID: 25661317
  11. Increasing the local concentrations of adenosine can either activate or inhibit O2 consumption via A1R, and this mechanism depends on Na(+) transport. PMID: 26010290
  12. Interaction between angiotensin II and adenosine in VSMC normally involves A1 receptor signalling PMID: 25251152
  13. We conclude that adenosine-stimulated exocytosis requires PKC- and ADAM17-dependent EGFR transactivation and that the function of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic domain. PMID: 25232008
  14. Both the quantitative PET data and immunohistochemical analysis indicate that A1Rs are upregulated in brain areas where active virus is present. PMID: 24513151
  15. These findings suggest that D1DR stimulation facilitates AMPAR function to initiate cocaine seeking in D1DR-containing direct pathway NAc neurons. A1AR stimulation inhibits both the facilitation of AMPAR function and subsequent cocaine seeking. PMID: 23598433
  16. Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength. PMID: 23613526
  17. Antinociceptive activity is mediated by the adenosine A1 receptor system in the spinal cord, linked to activation of opioid receptors in adult animals with inflammation. PMID: 23810661
  18. Inhibition of adenosine A receptors blocked Ca oscillations in smooth muscle cells and airway contraction induced by local epithelial injury. PMID: 23221044
  19. N6-cyclopentyladenosine, an adenosine A1 receptor agonist dose-dependently inhibited cardiomyocyte protein synthesis and hypertrophy induced by TNF-alpha. PMID: 21993001
  20. Extracellular ATP reduces epileptiform activity via activation of adenosine A1 receptors. PMID: 23106524
  21. The present study was designed to determine whether and how adenosine receptor activation induces translocation of PKCepsilon to mitochondria. PMID: 22233927
  22. Data suggest that expression of Adora1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; studies include investigation of gene expression under influence of Adora1 agonists. PMID: 22449383
  23. Adenosine A1 receptor density is not changed between exercise groups of adult and middle aged rats, but treadmill running counteracted the age-related increase in adenosine A2A receptor densities. PMID: 22064330
  24. Activation of adenosine A receptors could contribute to antidepressant effects. PMID: 22323824
  25. Adenosine A1 receptors are possibly involved in the modulation of rhythmical respiration through the inhibitory synaptic input from inspiration-related neurons. PMID: 15719142
  26. Presynaptic adenosine A receptors decrease action potential-dependent glutamate release from trigeminal primary afferents onto medullary dorsal horn neurons and could be a potential target for the treatment of pain in orofacial tissues. PMID: 21878793
  27. Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors. Adenosine-induced inhibition was blocked by DPCPX,a selective A1 receptor antagonist, but not by DMPX, a selective A2 receptor antagonist. PMID: 20054814
  28. Our data indicate that the actions of adenosine on mEC layer II stellate neurons is accentuated in temporal lobe epilepsy due to an upregulation of adenosine A(1)-receptors. PMID: 22126400
  29. Data show that A(1)R activation can prevent the progression to SE and suggest that reduced A(1)R signaling promotes the transition of seizures to SSSE. PMID: 22150479
  30. Adenosine A1 receptor-induced postconditioning in a rat heart embryo cell model hypoxia system is mediated by BK(Ca) potassium large conductance calcium-activated channels in vitro. PMID: 21186374
  31. (11)C-MPDX shows a regional distribution in rat brain consistent with binding to A(1)R PMID: 21764782
  32. data indicate atrial myocytes generate adenosine from extracellular AMP, which activates A(1) adenosine receptors (A(1)-R) in an autocrine fashion; chronic activation of A(1)-R causes parallel downregulation of both A(1)-R and muscarinic M(2) receptors PMID: 21061016
  33. These results suggest that activation of adenosine A receptor and in turn triggering p38 MAPK signaling may contribute to the low-frequency stimulation-induced depotentiation at hippocampal CA1 synapses. PMID: 18947392
  34. Activation of A(1)R or A(3)R by CCPA or Cl-IB-MECA, respectively, protects cardiomyocytes from hypoxia via phosphorylation of p38 MAPK, which is located downstream from the mitochondrial K(ATP) channel opening PMID: 20730620
  35. The vasodilatory response to adenosine in hepatic arteries of cirrhotic livers is mediated mainly by the adenosine A1 receptor. PMID: 20500549
  36. These findings suggest that wake-promoting perifornical-lateral hypothalamic area system is subject to increased endogenous adenosinergic inhibition and that adenosine acting via A(1) receptors, in part, inhibits HCRT neurons to promote sleep PMID: 20109537
  37. A1 adenosine receptors couple to channels in hippocampal CA3 pyramidal neurons, unexpectedly hyperpolarizing neuronal membrane potential via adenosine triphosphate (ATP)-sensitive potassium channels. PMID: 20237259
  38. This study pinpoints A(1) adenosine receptors as attractive targets for pharmacological interventions to reduce noise-induced cochlear injury after exposure. PMID: 19995597
  39. Antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin. PMID: 19093734
  40. activation of adenosine A1 receptors promotes the selective translocation of PKCvarepsilon and PKCdelta to the caveolin-enriched plasma membrane microdomains in cardiac myocytes. PMID: 19879903
  41. These results suggest that perifornical-lateral hypothalamic area (PF-LHA) is one of the sites where adenosine, acting via A1 receptors, inhibits PF-LHA neurons to promote sleep. PMID: 19781535
  42. The expression of a high density of A1AdoR that are efficiently coupled to a functional response enables the adipocyte to respond with high sensitivity to the low-affinity agonist, adenosine. PMID: 11906959
  43. Modulation of cardiac A1-adenosine receptors in rats following treatment with agents affecting heart rate. PMID: 11952152
  44. the differential expression of A(1) and A(2B) adenosine receptors in pituitary cells and provide evidence for opposing effects of adenosine on pituitary folliculostellate and endocrine cell growth PMID: 12021208
  45. The inhibition of neurogenic vasodilation by GR79236 is mediated via the activation of prejunctional adenosine A1 receptors. PMID: 12100087
  46. About 30% of hypothalamic orexin-containing neurons also contained the adenosine A1 receptor, suggesting a functional role of adenosine in the regulation of orexinergic activity. PMID: 12106679
  47. Activation of A1ARs with doses of cyclopentyladenosine that mimic the effects of high adenosine levels results in damage to the developing brain. PMID: 12151769
  48. adenosine A(1) receptors activate type 2a protein phosphatase (PP2a) and account for antiadrenergic effects in rat myocardial preparations. PMID: 12234781
  49. afferent inputs and intact glutamatergic transmission in the NTS are necessary to mediate the pressor and differential sympathoactivatory responses to stimulation of NTS A(1) receptors. PMID: 12234813
  50. Responses mediated by GABA B receptor and adenosine A1 receptor desensitize differently in presynaptic and postsynaptic compartments, and demonstrate the heterologous desensitization of postsynaptic adenosine A1 receptor responses. PMID: 12381818
  51. Rat A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity, not involving acute signaling through phosphoinositol-3-kinase in transgenic mice PMID: 12578815
  52. The Alpha(1) receptor-mediated modulation of GABAergic transmission may play an important role in the regulation of excitability of immature hippocampal CA1 neurons. PMID: 12626609
  53. our results indicate definite species differences as well as tissue differences between rat and guinea pig adenosine A1 receptors in isolated mammalian atrial and ventricular myocardium PMID: 12697266
  54. the membrane-proximal carboxyl terminus of the A1 adenosine receptor in receptor folding and G protein coupling PMID: 12764156
  55. Increase in plasma glucose is responsible for the higher gene expression of A1-AR in the liver of Streptozotocin-diabetic rats PMID: 12789654
  56. Recovery of respiratory function in C2-hemisected rats induced by chronic theophylline is unrelated to adenosine A1 receptor mRNA expression PMID: 12821393
  57. in hippocampus, adenosine A1 receptors are located in the active zone of presynaptic nerve terminals,in nerve terminals outside the active zone, in the postsynaptic density together with NMDA receptors and with N-and P/Q-type calcium channels PMID: 14499945
  58. Inhibition by FK 838 increased proximal tubular fluid output and the increased urinary Na(+) excretion returned to baseline values. PMID: 14993484
  59. Data suggest that purinergic activation of adenosine A1 receptors stimulates adenosine transporter CNT2 by a mechanism completely dependent on ATP-sensitive potassium channels. PMID: 15024061
  60. Complex pattern of A(1)R distribution in the Nucleus tractus solitarii (NTS), which highlight the powerful modulatory actions mediated by adenosine in the NTS barosensitive neurons. PMID: 15057516
  61. Treatment with adenosine-A1 receptor agonist(ARA) resulted in pronounced reductions of plasma free fatty acids, glycerol, and triglycerides. In Zucker fatty rats, ARA treatment caused an immediate improvement of peripheral insulin sensitivity. PMID: 15220221
  62. results suggest a possible involvement of adenosine A1 receptors during conditioning ischemia and of mitochondrial potassium ATP channels during subsequent severe ischemia in the development of tolerance to focal cerebral ischemia PMID: 15241185
  63. These data demonstrate that adenosine is capable of raising extracellular Kynurenic acid [KYNA] in the rat striatum by interacting with postsynaptic neuronal A1 receptors. This mechanism may result in a synergism between the effects of adenosine and KYNA PMID: 15255939
  64. ATP-mediated inhibitory responses may be, in part, related to production of endogenous nitric oxide, involvement of ATP-sensitive K+ channels, or activation of adenosine A1 receptors in lymphatic smooth muscle and endothelium. PMID: 15308482
  65. Treatment with 10 mM sodium azide for 2 h in normoxia caused a considerable decrease in the total ATP level; however, activation of adenosine A3 receptors significantly attenuated this decrease. PMID: 15681707
  66. Gene expression of adenosine A1 receptor was increased by ischemia probably due to the compensative response of brain. The raised adenosine A1 receptor may play a protective role in these damaged tissues. PMID: 16055264
  67. denosine A1 receptor subtype is responsible for the adenosine-induced ANP release and negative inotropism through adenylyl cyclase-cAMP pathway. PMID: 16286581
  68. Adenosine plays an inhibitory role in respiratory and metabolic regulation, in a way that A(1) receptors stimulation in the anteroventral preoptic region inhibits ventilatory drive during hypoxia and tonically modulates basal body temperature. PMID: 16352472
  69. Chronic caffeine treatment leads to modifications in the function of the A1R-adenosins a2a receptor PMID: 16481441
  70. Therapeutic strategies designed to exploit both the continued presence of adenosine and activity of A1 receptors could provide benefits in individuals who have suffered acute injury to the CNS. PMID: 16696848
  71. Protein phosphatase 2A is involved in adenosine A(1) receptor-mediated regulation of NHE1 activity in rat ventricular myocytes. PMID: 16707501
  72. suggests possible mechanisms by which such effective venous congestion may lead to cerebral protection and adenosine A1 receptor activation PMID: 17067559
  73. In compensated pressure-overload hypertrophy (POH) both mRNA and protein A1-receptor expression were significantly increased in left ventricular tissue. PMID: 17211253
  74. Striatal dopaminergic terminals contains adenosine A(1) receptors, which directly inhibit dopamine release independently of glutamatergic transmission. PMID: 17254024
  75. Glutamate release facilitation may involve an interaction of caffeine with presynaptic adenosine A1 receptors as adenosine A1 receptor inhibition abolished the caffeine-mediated facilitation of evoked glutamate release. PMID: 17372967
  76. A(1)AR receptor protein was found in the Peritumoural zone as a function of time of tumour development and tumour volume PMID: 17497078
  77. Receptor agonists blocked evoked potentials in olfacotry pathways but was inhibited by the antagonist DPCPX. PMID: 17512911
  78. Adora1 effect on GTP-protein binding in beta-adrenergic stimulated ventricular membranes is reported. PMID: 17516542
  79. Activation of A1 receptors of the entorhinal cortex has an anticonvulsant effect on piriform cortex kindled seizures. PMID: 17548208
  80. Adenosine contributes approximately 50% to insulin-stimulated muscle glucose transport by activating A1 adenosine receptor. PMID: 17622285
  81. Interactions between adenosine A1 and A2 receptors exert important modulatory influences on afferent arteriolar tone and autoregulatory capability. PMID: 17664389
  82. The theophylline mitigates the effects of C2 hemisection by attenuating the C2 hemisection-induced decrease in A1 protein levels. PMID: 17853654
  83. Adenosine A(1) receptor agonists and oxidative stress differentially modulate subcellular MAPKs. PMID: 17965278
  84. Activation of A(1) adenosine receptors in the nucleus of the solitary tract differentially inhibits/resets baroreflex control of regional sympathetic outputs. PMID: 17982009
  85. The A1R increase may be important in sleep homeostasis, since the increase in basal forebrain A1R density would increase the inhibitory effect of given level of adenosine, thus increasing the gain of the homeostat. PMID: 18007182
  86. Inhibition of dopamine release by adenosine A(1) receptors is dependent, at least in part, on the simultaneous activation of D(1) dopamine receptors. PMID: 18052983
  87. Repeated injections of agonist caused a decrease in adenosine A1 receptor numbers in the hippocampus and somatosensory cortex; agonist-induced hypothermia was significantly attenuated suggesting a functional desensitization of the A1 receptor system. PMID: 18163981
  88. small changes in membrane potential and [Ca2+]i in response to A1AR stimulation as compared to those of ANG II suggest that these 2 tissue hormones use different signal transduction mechanisms to affect JGC function, including inhibition of renin release. PMID: 18322364
  89. Prenatal diazepam exposure alter Adora1 mRNA expression in the brainstem respiratory center. PMID: 18360306
  90. This adenosine A(1) receptor-mediated modulation of GABAergic transmission onto TMN neurons may play an important role in the fine modulation of the excitability of TMN histaminergic neurons as well as the regulation of sleep-wakefulness. PMID: 18397365
  91. A1-ARs in the proximal tubules are increased by low salt intake and that A1-AR participates in the increased proximal tubule reabsorption of solute and fluid in response to low salt intake. PMID: 18480183
  92. These data suggest that 24 h sleep fragmentation induces long lasting but reversible impairments in ventilatory long-term facilitation and poikilocapnic hypoxic ventilatory response and these impairments require activation of adenosine A1 receptors. PMID: 18787037
  93. Findings support the hypothesis that central adenosine A(1)R signaling opposes the hypotensive response and explains absence of clonidine-evoked hypotension in conscious normotensive rats. PMID: 18849358
  94. These results suggest cerebral A(1)ARs are involved in effects of sleep deprivation and the regulation of sleep. PMID: 19146833
  95. activation of A(1) receptors decreases breathing rate and tidal volume and this occurs central to the cervical vagi; depression of tidal volume and the hypotensive response result from the excitation of central nervous A(1) expressing neurones. PMID: 19212009
  96. endogenous adenosine release promotes burst suppression (BS) patterns during reperfusion following transient cerebral ischemia and the endogenous A1R activation may be the primary underlying cause of post-ischemic BS patterns following brief ischemia PMID: 19344634
  97. in the cerebellar network, A1 receptor activation, known to decrease the excitatory output of granule cells, also increases their excitability by reducing their complex GABAergic input. PMID: 19477241
  98. Data suggest that adenosine A(1)receptor-mediated EGF receptor transactivation confers a neuroprotective effect in primary cortical neurons. PMID: 19574994

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Widely expressed in brain and spinal cord.
Database Links

KEGG: rno:29290

STRING: 10116.ENSRNOP00000004602

UniGene: Rn.32078

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