Recombinant Rat Adenylate cyclase type 8(Adcy8) ,partial

Code CSB-YP001344RA
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Source Yeast
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Code CSB-EP001344RA
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Source E.coli
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Code CSB-EP001344RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP001344RA
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Source Baculovirus
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Code CSB-MP001344RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Adcy8
Uniprot No. P40146
Alternative Names Adcy8Adenylate cyclase type 8; EC 4.6.1.1; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; Ca(2+)/calmodulin-activated adenylyl cyclase
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence.
Gene References into Functions
  1. Data show that the IL-1beta-dependent transdifferentiation of VSMCs is associated with the de novo expression of a new family of AC8 isoforms. These isoforms are catalytically inactive with dominant-negative effects, decreasing total cAMP production. The inhibitory effect of AC8E on adenylyl cyclases (ACs) activity is accompanied by the formation of heterodimers between AC8E and functional ACs. PMID: 29940197
  2. Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype. PMID: 22531884
  3. AC8 expression, besides being induced by the proinflammatory cytokine IL1beta, is also dependent on down-regulation of the Notch pathway occurring in an inflammatory context. PMID: 22613711
  4. Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8. PMID: 21771783
  5. Integration of PGE2 signals depend on the upregulation of calcium/calmodulin stimulable adenylyl cyclase 8. PMID: 16741924
  6. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. PMID: 19029295
  7. An IQ-like motif imparts calmodulin binding and autoinhibitory functions to adenylyl cyclcase 8. PMID: 19305019

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Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Tissue Specificity Brain.
Database Links

KEGG: rno:29241

STRING: 10116.ENSRNOP00000006789

UniGene: Rn.10382

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