Recombinant Rat Cadherin-17 (Cdh17), partial (Active)

Cadherin-17 mediates calcium-dependent cell–cell adhesion in intestinal and hepatic epithelia and is frequently overexpressed in gastrointestinal malignancies, where it contributes to tumor progression and metastasis. This recombinant protein spans residues 22–786, encompassing the extracellular cadherin domains critical for homophilic binding interactions, and demonstrates specific antibody recognition with an EC50 of 13.06–14.24 ng/mL in functional ELISA, confirming proper epitope presentation. Mammalian expression ensures native glycosylation and disulfide bond formation, features that support use in cell adhesion and spreading assays, tumor metastasis studies examining colorectal and gastric cancer models, and antibody development workflows requiring authentic conformational epitopes. The protein meets quality thresholds commonly required for functional binding studies, with purity exceeding 95% by SDS-PAGE and endotoxin levels below 1.0 EU/μg.