CDH17

CDH17, Cadherin-17, alias LI-cadherin. CDH17 is a member of the 7D-cadherin family whose extracellular domain consists of seven repetitive sequences, EC1-EC7, and whose intracellular domain contains 18-20 amino acids. CDH17 functions as a polypeptide transporter and cellular adhesion molecule to maintain the integrity of epithelial tissue. CDH17's adhesion mechanism differs from that of typical cadherins in that it does not require complexation with α- and β-catenins and is able to maintain adhesive function without interacting with other cytoplasmic components.
CDH17 is highly expressed in normal human cells only in the small intestine and colon, and is either not expressed or lowly expressed in other tissues such as the liver, heart, and kidney. However, in tumor tissues, CDH17 is overexpressed in gastric, pancreatic, hepatic, esophageal, cholangiocarcinomas and colorectal cancers, and its aberrant expression is closely associated with tumor formation and metastasis. CDH17 is a potential diagnostic marker and therapeutic target for malignant tumors of the digestive system.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 at 2μg/mL can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA1HU), the EC₅₀ is 3.095 to 4.451 ng/mL.

Recombinant Macaca fascicularis Cadherin 17 (CDH17), partial (Active) (CSB-MP4664MOV)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/ml can bind Anti-CDH17 recombinant antibody (CSB-RA613267MA3HU). The EC₅₀ is 2.182-2.529 ng/mL.

CDH17 Recombinant Monoclonal Antibody (CSB-RA613267MA1HU)

Validated Data

The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC₅₀ is 3.095-4.451 ng/mL.

Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2µg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

The following CDH17 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CDH17 Antibodies

CDH17 Proteins

CDH17 Antibodies

CDH17 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA613267ESR1HU	CDH17 Antibody	Human	ELISA, IHC
CSB-PA212083	CDH17 Antibody	Human	ELISA,WB,IF
CSB-PA006407	CDH17 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA017530LA01HU	PCDH17 Antibody	Human	ELISA, IF
CSB-PA017530LD01HU	PCDH17 Antibody, Biotin conjugated	Human	ELISA
CSB-PA017530LC01HU	PCDH17 Antibody, FITC conjugated	Human
CSB-PA017530LB01HU	PCDH17 Antibody, HRP conjugated	Human	ELISA
CSB-RA613267MA1HU	CDH17 Recombinant Monoclonal Antibody	Human	ELISA, FC

CDH17 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA882608ZA01MO	Cdh17 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

CDH17 Proteins

CDH17 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP005042RA CSB-EP005042RA CSB-BP005042RA CSB-EP005042RA-B	Recombinant Rat Cadherin-17 (Cdh17), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

CDH17 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP017530HU CSB-EP017530HU CSB-BP017530HU CSB-MP017530HU CSB-EP017530HU-B	Recombinant Human Protocadherin-17 (PCDH17), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP613267HU CSB-BP613267HU CSB-EP613267HU-B	Recombinant Human Cadherin-17 (CDH17), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP613267HU	Recombinant Human Cadherin-17 (CDH17), partial (Active)	Mammalian cell

CDH17 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-BP882608MO CSB-MP882608MO CSB-EP882608MO-B	Recombinant Mouse Cadherin-17 (Cdh17), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP882608MO	Recombinant Mouse Cadherin-17 (Cdh17), partial	E.coli
CSB-YP882608MO	Recombinant Mouse Cadherin-17 (Cdh17), partial	Yeast
CSB-MP882608MO1	Recombinant Mouse Cadherin-17 (Cdh17), partial	Mammalian cell

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CDH17

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