Recombinant Rat Glutathione S-transferase P (Gstp1)

1. The cytotoxic action of 2-acetylaminofluorene that give rise to the GST-P(+) single hepatocytes was suggested to be an injury to the excretory pump(s) and the duct of hepatocytes. A new physiological mechanism was hypothesized for the induction of preneoplastic cell populations in the rat liver instead of a genetic mechanism. PMID: 29501922
2. Data suggest that expression of Gstp1 can be regulated by dietary factors; here, Gstp1 is induced in hepatocytes by carnosic acid, an anticarcinogenic component of rosemary (Rosmarinus officinalis). PMID: 25974399
3. Data show that Valerian extract inhibits hepatocarcinogenesis by suppressing cell proliferation and inducing apoptosis in glutathione S-transferase pi GST-P(+) foci by activating gamma-aminobutyric acid A receptor GABA(A)RA1-mediated signaling. PMID: 25419570
4. Cisplatin metabolism in different organs of rats correlated positively with specific GSTP1 activities and this enzyme may be a critical determinant of extent of cellular uptake or retention of cisplatin in renal and liver tissues. PMID: 24474500
5. GSTP1 application early after myocardial infarction results in long-term beneficial structural and functional effects that prevent progression to heart faiilure. PMID: 24412522
6. GST-P(-) foci induced by promotion with agonists of peroxisome proliferator-activated receptor-alpha. PMID: 20423715
7. GSTpi directly associated with signal transducer and activator of transcription 3 (STAT3) to prevent Angiotensin II-triggered binding of Src to STAT3. PMID: 24321768
8. The change in expression of GST-pi in peripheral blood showed the same pattern as that in brain tissues, suggesting GST-pi might contribute to drug resistance in epilepsy. PMID: 22038365
9. GST-P-positive lesions may involve a mechanism facilitating lipid peroxidation PMID: 20091025
10. Exposure to diesel exhaust particles elevated transcription of glutathione-s-transferase gene in rat alveolar macrophages. PMID: 12011483
11. GSTpi proteins play an important role in the development of acquired drug resistance to various drugs of prostate cancer cells. PMID: 15809768
12. glutathione S-transferase P1 is induced by proteasome inhibitors PMID: 15863507
13. Hepaticcgene expression is upregulated by a limited availability of sulfur amino acids PMID: 15867277
14. GST-Pi expression was induced by the metabolites of cyclophoshamide. PMID: 16242832
15. Expression of GST-P gene is down-regulated by CCAAT enhancer-binding protein alpha in normal liver. PMID: 16407263
16. Drug resistant prostate cancer cells displayed significantly increased expression of GSTP1 with other prostate cancer cells. PMID: 16728343
17. The upregulation of MIF and GSTpi during the development of acquired drug resistance of hormone independent prostate cancer may modulate the activation of gp-170 PMID: 16728344
18. Expression of GST-P is correlated with cellular proliferation and is associated with risk and progression of oral cancer. PMID: 17596925
19. These data indicate that expression of GST-P may reflect the carcinogenic effect of cigarette smoke as well as the genetic susceptibility of animals in relation to continuous carcinogens exposure. PMID: 17786572
20. development of GST-P-negative foci during the early stage of hepatocarcinogenesis PMID: 18081878

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KEGG: rno:24426

STRING: 10116.ENSRNOP00000024601

UniGene: Rn.87063