Recombinant Rat Protein phosphatase 1 regulatory subunit 12A (Ppp1r12a), partial

1. Phos-tag SDS-PAGE thus provides a suitable and convenient method for analysis of the complex, multisite MYPT1 phosphorylation events involved in the regulation of myosin light chain phosphatase activity and smooth muscle contraction. PMID: 26864694
2. Both atorvastatin (10(-4) m) and Y-27632 (10(-6) m) pretreatment inhibited the phosphorylation of myosin phosphatase target subunit-1 (MYPT-1). PMID: 26610064
3. EGF induces Ca(2+) sensitization in vascular smooth muscle by Rho-kinase-dependent inactivation of MLCP mediated by the EGF receptor/MEK/Erk1/2 pathway PMID: 26004531
4. nuclear translocation of CaMKIIdelta3 following dephosphorylation at Ser(332) by PP1 likely accounts for BDNF expression and subsequent neurite extension and survival of dopaminergic neurons. PMID: 26163515
5. These results indicate that PPP1R12A indeed plays a role in skeletal muscle insulin signaling PMID: 24972320
6. During acute myocardial ischemia MYPT1 is targeted for degradation or proteolysis. Reduced MYPT1 expression results in a decrease in both tone and the sensitivity to NO-mediated SM relaxation of the peripheral vasculature. PMID: 23172397
7. In healthy young female rats, MLCK activity is higher and MLCP activity is lower in the bladder relative to the urethra PMID: 21070574
8. after hypoxia, increased myosin phosphatase target subunit 1 and myofibrillar protein phosphatase-1 activity impair aortic vasoreactivity through enhanced dephosphorylation of myosin light chain 20-kDa PMID: 12595284
9. Alteration of MYPT1 expression was part of a complex change in protein expression that can be generalized as a modulation from a phasic (fast) to a tonic (slow) contractile phenotype. PMID: 14704233
10. Congestive heart failure is associated with a decrease in the relative expression of the LZ+ MYPT1 isoform. Resistance to NO-mediated relaxation seen during CHF is a consequence of the decrease in the expression of the LZ+ MYPT1 isoform in smooth muscle. PMID: 15321927
11. pathway for the dynamic modulation of myosin light chain 2 phosphorylation through receptor-dependent phosphorylation of MYPT PMID: 15908465
12. C-terminus functions as an auto-inhibitory domain, and a central domain can mediate extensive reorganization of the actin cytoskeleton. PMID: 16106448
13. Phosphorylation of Thr695 and Thr850 on MYPT1 was detected in A7r5 cells, but Thr850 was preferred by Rho-kinase and Thr695 was phosphorylated by an unidentified kinase(s). PMID: 16297917
14. angiotensin converting enzyme inhibition prevents MYPT1 isoform switching, which would preserve normal flow, or NO-mediated vasodilatation in rats PMID: 16815432
15. There is a rapid reduction in MYPT1 expression in the small resistance mesenteric artery in a disease model of altered blood flow. PMID: 17293476
16. These results indicate that heat shock augments MYPT1 phosphorylation resulting in augmented vascular contraction. PMID: 17382904
17. Treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the MYPT1. PMID: 17880363
18. A new regulatory mechanism of myosin light-chain phosphatase via the interaction between 14-3-3 and MYPT1, is reported. PMID: 18094049
19. We propose that MYPT1 isoform switching is an adaptive response to reduce vascular resistance and maintain uterine blood flow in the setting of hypertension-triggered inward remodeling of the UAs in hypertension of pregnancy. PMID: 18094148
20. Ca2+ sensitization via phosphorylation of MYPT1 threonine-855 by Rho kinase contributes to the arterial myogenic response. PMID: 19359365

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KEGG: rno:116670

STRING: 10116.ENSRNOP00000006773

UniGene: Rn.162937