Recombinant Rat Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Ppp3ca)

1. FKBP12 can endogenously regulate calcineurin activity with therapeutic implications for the treatment of Parkinson's Disease. PMID: 29229832
2. 11R-VIVIT regulates the expression of NFATc1, and some other molecules in Calcineurin/NFAT signaling pathway PMID: 28478803
3. Results show that acute hyperammonemia induces hypophosphorylation of neuronal and glial intermediate filaments proteins in cerebral cortex of 21-day-old rats without affecting the hippocampus. In slices of cerebral cortex of 21-day-old animals, the cytoskeleton of astrocytes is more susceptible than neurons to ammonia toxicity, and this effect is mediated by PP2B and PP1 activities. PMID: 26936604
4. Calcineurin inhibitor tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin at the slit diaphragm. PMID: 27009276
5. modulation of Kv by PKA can be reversed by protein phosphatase 2B/calcineurin. PMID: 25793374
6. Prolonged oxidative stress-induced activation of calcineurin contributes to the attenuation of AMPK signalling and inhibits autophagy in cardiomyocytes. PMID: 24434520
7. Aerobic training did not cause any changes (p < 0.05) in CaN A or CaN B expression levels in either the soleus or the plantaris muscle. PMID: 23549689
8. the gamma-8 P/A-rich region is essential for binding calcineurin, suggesting that the gamma-8/calcineurin complex may regulate AMPA receptor phosphorylation and trafficking PMID: 24418105
9. PKCepsilon may negatively regulate adverse myocardial remodeling by cooperating with calcineurin to downregulate fibrosis and induce transcription of cardioprotective wound healing genes, including COX-2 PMID: 24298017
10. Calcineurin is fine-tuned to unique bandwidths and compute input variables in an asymmetric manner. PMID: 23602566
11. CNAalpha and CDK5 enzymatic activities are key determinants of release probability. PMID: 23699505
12. Fluoride might up-regulate the mRNA and protein expression of CaN, and the changes in CaN level may be involved in the increase of the bone turnover and could be one of the pathogenetic factors in fluorosis. PMID: 23302338
13. Homocysteine inhibits expression of 14-3-3epsilon and activates calcineurin in rat hippocampal neurons. PMID: 23139767
14. Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes. PMID: 23261540
15. The expression levels of both the catalytic A and regulatory B subunits of calcineurin were increased at 1 and 2 weeks, but not at 9 weeks, after the induction of streptozotocin diabetes. PMID: 22305959
16. hese data suggested an involvement of calcineurin in chronic constriction injury -elicited neuropathic pain. PMID: 21596102
17. This result indicates that the interaction of PMCA4 with calcineurin A plays a regulatory role in the signalling during catecholamine secretion. PMID: 21740891
18. we have identified calcineurin as a novel interaction partner for RAF1 and established a mechanistic link and possible therapeutic target for pathological cardiomyocyte hypertrophy induced by mutant RAF1 PMID: 21440552
19. KChIP2 can attenuate cardiac hypertrophy possibly through modulation of intracellular calcium concentration and calcineurin/NFAT pathway PMID: 20051248
20. Results describe the correlation between calcineurin and RANTES in rat apoptotic vascular smooth muscle cells stimulated by IFNgamma and CD40L. PMID: 20132097
21. Data demonstrate that calcineurin activity is a major determinant of PGC-1alpha expression in skeletal muscle during diabetes and possibly other conditions associated with loss of muscle mass. PMID: 20359506
22. Understanding alterations in CnA isoform distribution may help improve the targeting of current therapeutic interventions and/or the development of new treatments for TBI. PMID: 19751097
23. These results reveal the importance of regulated calcineurin binding to mAKAPbeta for the induction of cardiac myocyte hypertrophy. PMID: 19883655
24. cell-specific increase expression of myristoyltransferase and calcineurin in lung epithelium and endothelium PMID: 19916857
25. There is cross-talk between the calcineurin and JNK pathway in controlling renovascular hypertension-induced cardiac hypertrophy. PMID: 18957384
26. Calcineurin A alpha is significantly decreased in the particulate fractions but is not changed in the soluble fractions of the striatum of methamphetamine-sensitized rats. PMID: 11954050
27. The functional differences conferred upon CaN by the alpha or beta catalytic subunit isoforms suggest that the alpha:beta and CaN:substrate ratios may determine the levels of CaN phosphatase activity toward specific substrates. PMID: 12135494
28. CnA-alpha is upregulated in diabetic kidney glomeruli and collecting ducts and participates in regulation of AQP2 expression, phosphorylation, and function PMID: 15153553
29. Increased intraocular pressure leads to the initiation of a calcineurin-mediated mitochondrial apoptotic retinal ganglion cell death pathway in glaucoma. PMID: 16103353
30. The age-related formation of aggregates of the catalytic subunit of Cn was suggestive of a correlation between aggregate formation and diminished enzyme activity. The loss of Cn activity may alter signal transduction at synapses during the aging process. PMID: 16150427
31. The isolation and transport of calcineurin Aalpha and calcineurin Abeta in rat aortic smooth muscle cells are reported. PMID: 17303652
32. These findings further provide a link between the lipopolysaccharide-induced inflammatory response and the calcineurin/NFAT-3 signaling pathway that mediates the development of cardiac hypertrophy. PMID: 18398669
33. These results suggest that ET-1-induced cardiac hypertrophy is inhibited by activation of PPAR-gamma, which is at least partly due to cross-talk between PPAR-gamma and calcineurin/NFAT. PMID: 18600431
34. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. PMID: 19717566

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KEGG: rno:24674

STRING: 10116.ENSRNOP00000049674

UniGene: Rn.228648