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The CD34 recombinant monoclonal antibody is a highly specific antibody against the CD34 protein from human sources. This CD34 antibody was expressed by transfecting the human CD34 monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. Its isotype matches with the rabbit IgG. This CD34 antibody can be used in ELISA and IHC applications.
In preparation for bone-marrow transplantation, CD34 has been widely used as a marker to aid in the identification and isolation of hematopoietic stem cells (HSCs) and progenitors. It's also becoming more popular as a marker for identifying other tissue-specific stem cells, such as muscle satellite cells and epidermal precursors. CD34 is thought to boost progenitor cell proliferation while blocking its differentiation, and podocalyxin and CD34 work together to improve hematopoietic cell trafficking and migration.
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