CD86 Antibody

Datasheet

Code CSB-RA004965A0HU
Size US$350
Uniprot No. P42081
Image
  • Western Blot
    Positive WB detected in:Hela whole cell lysate
    All lanes:CD86 antibody at 0.55μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 70 KDa
    Observed band size: 70 KDa

Immunogen A synthesized peptide
Species Reactivity Human
Tested Applications ELISA, WB; Recommended dilution: WB:1:500-1:2000
Relevance Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Affinity-chromatography
Isotype Rabbit IgG
Clonality Monoclonal
Alias T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1, CD86, CD86, CD28LG2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Research Area Immunology
Gene Names CD86
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; FUNCTION
Subcellular Location Cell membrane, Single-pass type I membrane protein
Tissue Specificity Expressed by activated B-lymphocytes and monocytes.
Database Links

HGNC: 1705

OMIM: 601020

KEGG: hsa:942

STRING: 9606.ENSP00000332049

UniGene: Hs.171182

Pathway Toll-like receptor signaling pathway

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