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The CD86 recombinant monoclonal antibody is a highly specific antibody that recognizes the human protein CD86. This CD86 antibody was made by transfecting human CD86 monoclonal antibody gene-vector clones into a cell line for in vitro expression, then purifying the antibody using affinity chromatography from the tissue culture supernatant (TCS). The human CD86 monoclonal antibody was produced by immunizing mice with a human CD86 synthetic peptide. The isotype of this CD86 antibody is the same as rabbit IgG. This CD86 antibody is recommended for ELISA and WB.
CD86, also known as B7-2, is a transmembrane glycoprotein that is typically found on APCs such as macrophages, dendritic cells, and B cells. CD86 is a well-known costimulatory molecule that binds to CD28 and CTLA-4 on CD4+ T cells to augment or reduce T cell activation signals, respectively. And it is required for germinal center development. CD86 expression is modest in resting B cells, but it rises in response to BCR, CD40, IL-4R, LPS receptor, or 2-adrenergic receptor stimulation.
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