CD86, Cluster of differentiation 86, alias B7-2, CD28 ligand 2, is a co-stimulatory molecule expressed mainly on antigen-presenting cells and is a member of the immunoglobulin superfamily.CD86 is encoded by its own genes in human cells, and its mechanism of action is mainly by interacting with CD28 on the surface of T-cells, or with CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), providing co-stimulatory signals that promote T-cell activation and differentiation. providing co-stimulatory signals, thereby promoting T cell activation, proliferation and differentiation. In M1-type macrophages (pro-inflammatory macrophages), the expression level of CD86 is usually high, which can bind to CD28 of T cells and promote T cell activation, enhancing immune response and inflammatory response .
In a biological sense, CD86 plays an important role in the immune response. It is involved in the activation process of T cells and is essential for maintaining immune homeostasis and regulating the strength of immune response. In addition, the expression of CD86 has been associated with the development of certain diseases, such as in autoimmune diseases and chronic inflammatory diseases, where aberrant expression of CD86 may lead to dysregulation of the immune response. Therefore, therapeutic strategies targeting CD86 are being investigated for the treatment of related diseases .
CD86 Recombinant Monoclonal Antibody (CSB-RA004965A0HU)
Validated Data
Western Blot
Positive WB detected in Hela whole cell lysate
All lanes CD86 antibody at 0.55μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 KDa
Observed band size: 70 KDa
The following CD86 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CD86 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004965GA01HU | CD86 Antibody | Human, Rat | ELISA, WB, IHC, IF, FC |
CSB-PA004965EA01HU | CD86 Antibody | Human | ELISA |
CSB-RA004965A0HU | CD86 Recombinant Monoclonal Antibody | Human | ELISA, WB |
CD86 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004959MO | Recombinant Mouse T-lymphocyte activation antigen CD80 (Cd80) | in vitro E.coli expression system |
CSB-CF004965MO | Recombinant Mouse T-lymphocyte activation antigen CD86 (Cd86) | in vitro E.coli expression system |
CSB-YP004959MO1 CSB-EP004959MO1 CSB-BP004959MO1 CSB-MP004959MO1 CSB-EP004959MO1-B |
Recombinant Mouse T-lymphocyte activation antigen CD80 (Cd80), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-YP004965MO1 CSB-EP004965MO1 CSB-BP004965MO1 CSB-MP004965MO1 CSB-EP004965MO1-B |
Recombinant Mouse T-lymphocyte activation antigen CD86 (Cd86), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD86 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004965HU | Recombinant Human T-lymphocyte activation antigen CD86 (CD86) | in vitro E.coli expression system |
CSB-YP004965HU1 CSB-EP004965HU1 CSB-BP004965HU1 CSB-MP004965HU1 CSB-EP004965HU1-B |
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP005161HU | Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) | Mammalian cell |
CD86 Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-CF004965RB | Recombinant Rabbit T-lymphocyte activation antigen CD86 (CD86) | in vitro E.coli expression system |
CSB-YP004965RB1 CSB-EP004965RB1 CSB-BP004965RB1 CSB-MP004965RB1 CSB-EP004965RB1-B |
Recombinant Rabbit T-lymphocyte activation antigen CD86 (CD86), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD86 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL004959MO | Mouse T-lymphocyte activation antigen CD80(CD80) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
CD86 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08542h | Human soluble Cluster of differentiation 86,sCD86 ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |