CDH6 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA005055MA1HU
Size	US$210
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Image	The Binding Activity of Human CDH6 with Anti-CDH6 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH6 (CSB-MP005055HU1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC₅₀ is 2.421-2.802 ng/mL. The Binding Activity of Mouse CDH6 with Anti-CDH6 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse CDH6 (CSB-MP005055MO1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC₅₀ is 1.884-2.164 ng/mL. The Binding Activity of Rat CDH6 with Anti-CDH6 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat CDH6 (CSB-MP005055RA1) at 2 μg/mL can bind Anti-CDH6 recombinant antibody. The EC₅₀ is 1.630-1.837 ng/mL.
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Target Background

Product Details

Uniprot No.

P55285

Target Names

CDH6

Alternative Names

CDH6 Recombinant Monoclonal Antibody

Species Reactivity

Human, Macaca fascicularis, Rat

Immunogen

Recombinant Human CDH6 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

8B4

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Gene References into Functions

Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in Cholangiocarcinoma (CC).Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC PMID: 27593557
The chromatin modifications were determined at five PRC2 targets commonly underexpressed in multiple myeloma (CIITA, CXCL12, GATA2, CDH6 and ICSBP/IRF8). The selected genes were confirmed to be underexpressed in MM compared to normal plasma cells. PMID: 20634887

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.

Database Links

HGNC: 1765

OMIM: 603007

KEGG: hsa:1004

STRING: 9606.ENSP00000265071

UniGene: Hs.124776

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Related pathways

Target Therapy

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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CDH6 Recombinant Monoclonal Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background