FABP4 Antibody

Code CSB-RA007945A0HU
Size US$350
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Product Details

Uniprot No. P15090
Target Names FABP4
Alternative Names 3T3-L1 lipid-binding protein antibody; 422/aP2 antibody; A-FABP antibody; adipocyte antibody; Adipocyte lipid binding protein antibody; Adipocyte lipid-binding protein antibody; Adipocyte protein AP2 antibody; Adipocyte-type fatty acid-binding protein antibody; AFABP antibody; ALBP antibody; ALBP/Ap2 antibody; aP2 antibody; Epididymis secretory protein Li 104 antibody; FABP antibody; FABP4 antibody; FABP4_HUMAN antibody; Fatty acid binding protein 4 adipocyte antibody; Fatty acid binding protein 4 antibody; Fatty acid binding protein adipocyte antibody; Fatty acid-binding protein 4 antibody; Fatty acid-binding protein antibody; HEL S 104 antibody; Lbpl antibody; Myelin P2 protein homolog antibody; P15 antibody; P2 adipocyte protein antibody; Protein 422 antibody
Species Reactivity Human
Immunogen A synthesized peptide derived from human FABP4
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Monoclonal
Isotype Rabbit IgG
Purification Method Affinity-chromatography
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
Gene References into Functions
  1. FABP4 shows potential as a novel biomarker for diabetic retinopathy prediction in Chinese patients with type 2 diabetes (T2DM), and strict glycemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4. PMID: 29305311
  2. association between serum FABP4 concentrations and sarcopenia in chronic hemodialysis patients PMID: 29935964
  3. intermittent high glucose potentiates A-FABP activation and inflammatory responses via TLR4/p-JNK signaling in THP-1 cells PMID: 29850615
  4. High serum A-FABP concentration is associated with peripheral arterial disease in women, but not men, with type 2 diabetes mellitus. PMID: 28303680
  5. FABP4 from adipocytes mediate adipocyte-cholangiocarcinoma interactions that are crucial for the invasion, migration and epithelial-mesenchymal transition of cholangiocarcinoma cells PMID: 29237483
  6. Compared with the low arterial stiffness group, the high arterial stiffness group had higher values for age, systolic blood pressure, pulse pressure, duration of kidney transplantation and serum A-FABP PMID: 28660445
  7. Blood FABP4 is a biomarker for metabolic syndrome and cardiovascular disease independently of HIV status and antiretroviral therapy. PMID: 29304747
  8. Increased FABP4 blood level is a biomarker of lead exposure in women. PMID: 29264639
  9. ubiquitylation destabilizes the fold of two proteins, FKBP12 and FABP4 PMID: 27991582
  10. Compared to control group, breast cancer patients show higher FABP4 and FABP5 blood levels. Our data suggest that, particularly, circulating FABP4 levels could be considered a new independent breast cancer biomarker. Our work translates basic science data to clinic linking the relationship between adipose tissue and lipid metabolism to breast cancer. PMID: 28701570
  11. findings reveal a pro-angiogenic role of FABP4 in first trimester placental trophoblast cells and its regulation may have impact in placental physiology. PMID: 28620819
  12. A-FABP concentration was an independent predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention. PMID: 29017449
  13. Ectopic expression and secretion of FABP4 in vascular endothelial cells contribute to neointima formation after vascular injury. PMID: 28903937
  14. Elevated A-FABP concentration could be a predictor for MetS and arterial stiffness in hypertensive patients PMID: 28860092
  15. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. PMID: 27270834
  16. Increased second trimester plasma FABP4 independently predicted GH/PE in GDM patients PMID: 29394285
  17. our research demonstrated that high FABP3 or FABP4 expression had strong prognostic value for overall survival in non-small cell lung cancer PMID: 27323829
  18. The distribution of genotype frequencies in the assessed women (PON1 Q192R polymorphism) was QQ = 20%, QR = 48% and RR = 32%. Significantly higher serum FABP4 levels were found in women with genotype QR/RR (20.6 +/- 2.20 ng/mL), when compared with the levels found in the QQ group (12.8 +/- 1.70 ng/mL) (p = .004). PMID: 27712128
  19. serum A-FABP levels were increased significantly in normoglycemic individuals with a first-degree family history of diabetes; the use of serum A-FABP as a biomarker in the first-degree relatives of patients with diabetes may result in overestimation of the risk of obesity-induced metabolic disease and cardiovascular disease PMID: 27534843
  20. Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4, CSNK1E and NEFH could become potentially useful biomarkers for schizophrenia. PMID: 27236410
  21. Circulating levels of AFABP and EFABP are not decreased in Lipodystrophy despite adipose tissue loss in contrast to other adipokines including leptin and adiponectin. PMID: 28088613
  22. Taken together, PPAR gamma and FABP4 gene expression levels in PBMCs [peripheral blood mononuclear cells] may be indicators of metabolic factors and body composition components. PMID: 27563749
  23. eFABP4 induces ER stress and potentiates the effect of linoleic acid in HepG2 cells, suggesting that FABP4 could be a link between obesity-associated metabolic abnormalities and hepatic insulin resistance mechanisms PMID: 27155388
  24. Increased second-trimester FABP4 independently predicted pre-eclampsia in women with type 1 diabete and significantly improved reclassification and discrimination. PMID: 27630211
  25. High levels of FABP4 are significantly related to stroke risk and severity, independent from other traditional and emerging risk factors, suggesting that they may play a role in stroke pathogenesis. PMID: 28781090
  26. We found that serum FABP4 concentration were associated with insulin resistance and secretion in type 2 diabetes mellitus. This suggests that FABP4 may play an important role in glucose homeostasis. PMID: 28654680
  27. High FABP4 expression is associated with ovarian cancer. PMID: 27568980
  28. AFABP levels were higher in neonates compared with adults. Preterm infants had higher AFABP levels compared with full-term infants. Among full-term infants, AFABP levels in SGA infants were lower, compared with appropriate for gestational age and large for gestational age infants. PMID: 28324040
  29. Exogenous FABP4 plays a key role in tumor proliferation and activates the expression of fatty acid transport proteins in MCF-7 breast cancer cells. PMID: 27061264
  30. High FABP4 expression is associated with Acute Monocytic Leukemia. PMID: 28108519
  31. FABP4 over-expression in cardiomyocytes can aggravate the development of cardiac hypertrophy through the activation of ERK signal pathway. PMID: 27294862
  32. Results show that serum FABP4 levels were significantly increased in patients with psoriasis. PMID: 27864793
  33. secreted FABP4 and FABP5 from adipocytes as adipokines differentially affect transcriptional and metabolic regulation in ADSC near adipocytes PMID: 27936164
  34. FABP4 locally produced by epicardial/perivascular fat and macrophages in vascular plaques contributes to the development of coronary atherosclerosis. PMID: 27013610
  35. Elevated levels of FABP4 are associated with higher cardiovascular mortality among men with type 2 diabetes. PMID: 27609367
  36. These genes should be at the downstream of signal pathways and be regulated by the 23 genes identified before. Our findings may provide a unique new model for studying the molecular control of cattle cross-talk between adipose and skeletal muscle. PMID: 27856250
  37. higher serum A-FABP level is positively associated with MetS in type 2 DM patients PMID: 28042581
  38. FABP4 level was independently associated with gender, adiposity, renal dysfunction, and levels of cholesterol. PMID: 27241838
  39. FABP4 DNA hypomethylation induced by Hcy may be involved in the overexpression of FABP4, thereby inducing cholesterol accumulation in macrophages. PMID: 27221153
  40. Study found that the fasting insulin and age-adjusted AFABP concentrations were significantly higher in the gestational diabetes mellitus group of women compared with the normal glucose tolerance participants in the mid- and late stages of pregnancy. PMID: 27181269
  41. mTOR/FABP4 signaling pathway directly regulates the proliferation of endothelial cells in hemangioma. Rapamycin and inhibitors of FABP4 have therapeutic potential for treating infantile hemangiomas. PMID: 27914823
  42. Results suggested that the expression of a lipid metabolism-related gene and an important SNP in the 3'-UTR of FABP4 are associated with TNBC prognosis. PMID: 26959740
  43. In multiple linear regression stepwise analysis, BMI, HbA1C, and HOMA-IR were significantly independent determinants for A-FABP. BMI, HbA1C, and HOMA-IR are independently associated with A-FABP in obese subjects with newly diagnosed type 2 diabetes. A-FABP may be related to insulin resistance and inflammation in type 2 diabetes and concomitant obesity. PMID: 27819006
  44. The increase in placental FABP4 expression in preeclampsia may affect the function of trophoblast, and this increase may have a role in the pathogenesis of preeclampsia. PMID: 26992681
  45. our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells. PMID: 26687459
  46. results underline a gender difference in FABP4 secretion in stable COPD patients. PMID: 26823558
  47. Increased FABP4 level showed increased risk for reduced lung function in subjects with normal ventilatory function. PMID: 26887419
  48. High FABP expression is associated with Sepsis. PMID: 27089280
  49. Serum irisin might exert antagonistic effects on FABP4 in the middle-aged Chinese population. PMID: 26752184
  50. Urinary FABP4 level is independently correlated with level of albuminuria and possibly predicts yearly decline of estimated glomerular filtration rate. Urinary FABP4 would be a novel biomarker of glomerular damage. PMID: 25506691
  51. FABP4 is functionally expressed in endometrial epithelium and is necessary for maintaining the cell function of epithelial cells of endometrium. PMID: 25572488
  52. Fatty acid binding protein 4 expression is detected in arteriovenous malformations and cavernous malformations in a subset of endothelial cells and some perivascular fibroblast-like vimentin-positive cells. PMID: 24865546
  53. Our data suggest that FABP4 in glomerular mesangial cells is up-regulated in diabetic nephropathies and FABP4 mediates apoptosis via the ER stress in human mesangial cells. PMID: 25958041
  54. FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages. PMID: 25897794
  55. Biological network analysis of differentially regulated genes revealed that FABP4, ADIPOQ and RBP4 were most down regulated genes, sharing strong connection with the other molecules of lipid metabolism pathway. PMID: 25923423
  56. Gene-environment interactions studies found significance association between selenium and rs2290201 in FABP4 for total and LDL cholesterol levels and rs1800774 in CETP for elevated LDL cholesterol. PMID: 25606668
  57. These findings indicate that exogenous FABP4 interacts with plasma membrane proteins, specifically CK1. PMID: 26343611
  58. The binding of FABP4 towards a group of small molecules structurally related to the nonsteroidal anti-inflammatory drug ibuprofen was analyzed through X-ray crystallography. PMID: 25664790
  59. we identify adipocyte-type fatty acid-binding protein (A-Fabp) and other members of the fatty acid-binding protein (Fabp) family as interaction partners of Cgi-58. PMID: 25953897
  60. High expression level of FABP4 is associated with increased incidence of residual disease in high-grade serous ovarian cancer after surgery. PMID: 24756370
  61. Circulating FABP4 may prove useful as a prognostic biomarker in risk stratification of patients with acute coronary syndrome. PMID: 26069234
  62. Serum A-FABP levels were associated with fat mass, and were also influenced by visceral fat area after menopause in Chinese women without diabetes mellitus. PMID: 25719934
  63. Increased plasma levels of FABP4 and PTEN is associated with more severe insulin resistance in women with gestational diabetes mellitus. PMID: 25659997
  64. A-FABP is more strongly associated with some cardiometabolic risk factors in premenopausal than in postmenopausal women. PMID: 24971341
  65. Palmitate activation by FATP4 triggers hepatocellular apoptosis via altered phospholipid composition and steatosis by acylation into complex lipids. PMID: 25603556
  66. The serum level of A-FABP is not a predictor of a positive SPECT result PMID: 25123032
  67. Critically ill patients have higher serum A-FABP concentrations. PMID: 23375099
  68. FABP4 rs77878271 is a novel variant affecting serum total cholesterol levels and cardiovascular risk PMID: 25122052
  69. Serum A-FABP levels were not different between patients with essential hypertension and normal controls. PMID: 24491219
  70. Serum FABP4 concentration and systolic blood pressure after 10 min standing in an orthostatic test at 24 weeks are associated with subsequent development of pregnancy-induced hypertension in overweight women. PMID: 25130095
  71. Among individuals aging more than 65 years included in the study, serum A-FABP was inversely associated with liver steatosis. PMID: 24150574
  72. Data suggest that two adipokines, adipocyte fatty acid-binding protein (FABP4) and lipocalin-2 (LCN2), function as pivotal modulators of vascular function and may be involved in pathogenesis of atherosclerosis in obese subjects. [REVIEW] PMID: 24214285
  73. FABP4 is actively released from human adipocytes in vitro via a non-classical, calcium-dependent mechanism. PMID: 24352293
  74. AP2 is a negative regulator of osteoblast differentiation and mineralization. PMID: 25369469
  75. Elevation of circulatng FABP4 levels was associated with left ventricular dysfunction in a general population. PMID: 25142635
  76. A strong association was found between adipocyte fatty acid binding protein and FGF 21 levels in metabolic syndrome individuals. PMID: 24397811
  77. Serum A-FABP levels independently and positively correlate with subclinical atherosclerosis in pre- and postmenopausal Chinese women with normal glucose tolerance after adjustments for the traditional risk factors PMID: 25127012
  78. Serum A-FABP concentrations correlate significantly with visceral fat area, metabolic syndrome, and predicted significant myocardial ischemia on single-photon emission computed tomography . PMID: 24842767
  79. It also provides a link between DLL4-NOTCH and FOXO1-mediated regulation of endothelial gene transcription, and it shows that DLL4-NOTCH is a nodal point in the integration of pro-angiogenic and metabolic signaling in endothelial cells. PMID: 24939870
  80. Cardiac surgery increased A-FABP mRNA expression in peripheral monocytes. PMID: 24182337
  81. FABP4 overexpression is associated with prostate cancer progression. PMID: 24740818
  82. Fatty acid-binding protein 4 levels increased and retinol-binding protein 4 levels did not change during moderate weight loss in obese women with metabolic syndrome. PMID: 23979787
  83. Circulating FABP4 is involved in the metabolic disturbances of systemic lupus erythematosus, affecting lipid metabolism and IR, and it could be a biomarker of atherosclerosis in this population. PMID: 24390652
  84. FABP4 plays an important role in the cell growth of oral squamous cell carcinoma through the MAPK pathway. PMID: 24425381
  85. Results suggestive of bi-directional interaction between FABP4 and PPARgamma pathways that may be driving aggressive tumor cell behavior in bone. PMID: 24240026
  86. Serum a-FABP is positively correlated to body fat content, especially to trunk fat in HIV infected children on highly-active-antiretroviral-therapy. PMID: 24266781
  87. results demonstrate that the FABP4-induced DNA synthesis and cell migration are mediated primarily through a MAPK-dependent pathway that activates the transcription factors c-jun and c-myc in HCASMCs PMID: 24312381
  88. High serum A-FABP levels were significantly associated with complex coronary lesions in patients with stable CAD, suggesting that high A-FABP levels may be involved in coronary plaque vulnerability. PMID: 23224329
  89. Associations of common single nucleotide polymorphisms and haplotypes in the FABP4 gene with lower plasma FABP4 but higher fasting glucose levels. PMID: 24043587
  90. FABP4 is upregulated in response to PUFA oxidation end-products in human macrophages in a pathway involving Akt and ERK/Nrf2 PMID: 24075747
  91. found that FABP4 level was higher and PPARgamma level was lower in human visceral fat and mouse epididymal fat compared with their subcutaneous fat PMID: 24319114
  92. A-FABP seems to be a valuable predictor of atherogenic risk profile PMID: 24044564
  93. we found the increased expression of FABP4 in rheumatoid synovial tissue, synovial fluid and in the blood circulation. These increased FABP4 levels positively correlated with serum cholesterol levels, independent of rheumatoid arthritis disease activity. PMID: 23714112
  94. Insulin sensitizing and lipid lowering therapies do not affect free fatty acid binding (RBP)4 levels in polycystic ovary syndrome patients. PMID: 23480783
  95. Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in patients with coronary artery disease. PMID: 23866022
  96. FABP4 is associated with the clinical manifestations and biomarkers of heart failure (HF), and is associated with obesity and diabetes in HF patients. It exhibits a parallel evolution with the circulating levels of NT-proBNP in HF patients. PMID: 23642261
  97. High Fabp4 expression is associated with atherosclerotic lesion. PMID: 23387955
  98. The inhibition of macrophage FABP4 expression can be attributed to the antiatherogenic properties of tamoxifen. PMID: 23805908
  99. In overweight and obese women, FABP4 showed an independent association with parameters of left ventricular remodelling. PMID: 23598540
  100. Data suggest that the reduction of FABP4 serum levels may contribute to the preventive effect of lipoprotein apheresis on cardiovascular events. PMID: 23357154

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Subcellular Location Cytoplasm, Nucleus
Protein Families Calycin superfamily, Fatty-acid binding protein (FABP) family
Database Links

HGNC: 3559

OMIM: 600434

KEGG: hsa:2167

STRING: 9606.ENSP00000256104

UniGene: Hs.391561

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