Code | CSB-RA950991A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
IHC | 1:50-1:200 |
FC | 1:50-1:200 |
The GLA recombinant monoclonal antibody is synthesized in vitro through a systematic process. Initially, GLA antibody genes are isolated from B cells derived from immunoreactive rabbits. These genes undergo amplification and are cloned into phage vectors, which are subsequently introduced into mammalian cell lines to facilitate the generation of functional antibodies. The resulting GLA recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography. It shows reactivity with human GLA protein and can be used in ELISA, IHC, and FC applications.
GLA is primarily active in lysosomes, cellular organelles responsible for breaking down various molecules. Alpha-galactosidase A (GLA) mainly catalyzes the hydrolysis of the alpha-galactosides. This enzyme plays a crucial role in the breakdown of complex carbohydrates in the body, particularly a substrate known as globotriaosylceramide (Gb3), also called ceramide trihexoside.
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