Code | CSB-RA616248A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The HTR2C recombinant monoclonal antibody can detect human HTR2C protein in ELISA, WB, and IHC applications. It is produced through recombinant DNA technology. The gene coding for the HTR2C monoclonal antibody is synthesized by sequencing the cDNA of the HTR2C antibody-producing hybridomas. These hybridomas are created by fusing myeloma cells with B cells taken from an animal that was immunized with a synthesized peptide derived from human HTR2C. The synthesized gene is then cloned into a vector and transfected into cells for cultivation. Finally, the resulting HTR2C recombinant monoclonal antibody is purified through affinity chromatography from the cell culture supernatant.
The HTR2C protein mainly regulates the activity of serotonin, a neurotransmitter that plays a critical role in the brain. The HTR2C protein is primarily expressed in the brain. When serotonin binds to the HTR2C receptor, it activates a signaling pathway that leads to changes in the activity of certain neurons. The HTR2C protein is involved in a range of physiological processes, including mood regulation, appetite, and sleep, and dysfunction of this protein has been associated with various neuropsychiatric disorders such as depression, anxiety, and eating disorders.
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