Code | CSB-RA011088A0HU |
Size | US$210 |
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The IGF2 recombinant monoclonal antibody is produced using DNA recombinant technology and in vitro genetic manipulation. It begins with immunizing an animal with a synthesized peptide derived from human IGF2, followed by the isolation and selection of positive B cells. Through screening and single clone identification, the B cells with the desired properties are chosen. The genes encoding the light and heavy chains of the IGF2 antibody are then amplified using PCR and inserted into a plasmid vector. This recombinant vector is transfected into a host cell line for the expression of the antibody. The IGF2 recombinant monoclonal antibody is purified from the cell culture supernatant using affinity chromatography. It is specifically designed to target human IGF2 protein and is recommended for use in ELISA.
The IGF2 protein is a growth factor that plays a critical role in embryonic development, cell growth, and tissue differentiation. It is primarily produced in the liver and acts as a mitogen, promoting cell proliferation and survival. IGF2 also plays a role in regulating metabolism, including glucose uptake and lipid metabolism, as well as muscle development and bone growth. Dysregulation of IGF2 expression has been observed in cancer and other diseases.
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