Code | CSB-RA251959A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The preparation of the IL23A recombinant antibody is a multi-step process. It starts with sequencing the gene that encodes the IL23A monoclonal antibody and cloning the gene into a plasmid vector. The next step is to transfect the recombinant vector into a host cell line. Finally, the IL23A recombinant monoclonal antibody is purified from the cell culture supernatant using affinity chromatography. The IL23A monoclonal antibody is derived from the IL23A antibody-producing hybridomas, using a synthesized peptide derived from human IL23A as the immunogen. This antibody is recommended for use in ELISA and WB applications to detect human IL23A protein.
IL23A is a subunit of the IL-23 cytokine and plays a key role in the immune system by regulating the differentiation, proliferation, and activation of T cells. Specifically, it is involved in the differentiation of Th17 cells, a subset of T cells that produce the cytokine IL-17. Th17 cells have been implicated in the pathogenesis of various autoimmune and inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. IL-23A binds to its receptor, IL-23R, which is expressed on the surface of various immune cells, including T cells and natural killer cells. This activates a signaling cascade that results in the activation of transcription factors, such as STAT3, which regulate the expression of genes involved in T cell differentiation and activation.
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