ILF2 Recombinant Monoclonal Antibody

1. this study identifies a new role of ILF2 in the regulation of the NLRP3 inflammasome. PMID: 29655789
2. High expression of ILF2 was tightly correlated with lymph node metastasis, pathological stage and poor clinical prognosis in gastric cancer. PMID: 28831206
3. ILF2 interacts with RNA-binding proteins involved in the DNA damage response. PMID: 28669490
4. The data suggest that features of both the N- and C-termini of NF90 participate in the heterodimerization with NF45 and that the formation of NF90-NF45 changes the conformation of NF90's RNA-binding motifs to a status in which the co-operative interplay of the RNA-binding motifs is optimal. PMID: 28062840
5. NF90-NF45 stimulates an elevation of EGF receptor levels via the suppression of miR-7 biogenesis, resulting in the promotion of cell proliferation in Hepatocellular Carcinoma. PMID: 27519414
6. The results revealed that ILF2 is regulated by miR-7 and suggest that downregulation of miR-7 may be an important factor for the ILF2 overexpression in pancreatic carcinoma. PMID: 28259961
7. Deletion of the RNA binding domains of NF45 and NF90 diminished the enhancement of HIV infection and gene expression. PMID: 26891316
8. NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma. PMID: 26276310
9. Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis PMID: 26059795
10. The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators. PMID: 26381409
11. NF45 and NF90 are novel higher-eukaryote-specific factors required for the maturation of 60S ribosomal subunits. PMID: 26240280
12. These findings suggested that NF45 might play an important role in promoting the tumorigenesis of ESCC, and thus be a promising therapeutic target to prevent ESCC progression. PMID: 25286760
13. These results suggest a novel molecular mechanism for the modulation of RNA granule assembly and disassembly by NFAR2, NF45, and phosphorylation at double-stranded RNA-activated kinase PKR sites. PMID: 24920670
14. These findings indicate that NF45 plays an important role in the growth regulation of glioma cells PMID: 25023405
15. AU-rich 5' UTRs harboring internal ribosome entry sites are regulated by NF45. NF45 regulates XIAP protein levels through interaction with its IRES. PMID: 23129811
16. The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining PMID: 21969602
17. ILF2 recruits a DNA-associated replication and transcription complex, of which it is a part, to its target DNA sequence. PMID: 20808282
18. The data presented are consistent with a model in which translation of cIAP1 is governed, at least in part, by NF45, a novel cellular IRES trans-acting factor. PMID: 19893574
19. plays important role in protein priming of HBV polymerase PMID: 11958450
20. NF45 is a is a highly conserved transcriptional activator of the gene IL-2. PMID: 15817156
21. Cell growth is retarded and giant multinucleated cells accumulate when the expression of NF45 or NF90, but not NF110, is reduced in HeLa cells. PMID: 18458058
22. Results suggest that the association of the NF90-NF45 complex with pri-miRNAs impairs access of the Microprocessor complex to the pri-miRNAs, resulting in a reduction of mature miRNA production. PMID: 19398578

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HGNC: 6037

OMIM: 603181

KEGG: hsa:3608

STRING: 9606.ENSP00000355011

UniGene: Hs.75117