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INA Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA268828A0HU
Size US$210
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Image
  • IHC image of CSB-RA268828A0HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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Product Details

Uniprot No.
Q16352
Target Names
INA
Alternative Names
66 kDa neurofilament protein antibody; AINX_HUMAN antibody; Alpha Inx antibody; Alpha-internexin antibody; Alpha-Inx antibody; INA antibody; Internexin neuronal intermediate filament protein alpha antibody; MGC12702 antibody; NEF 5 antibody; NEF5 antibody; Neurofilament 5 (66kD) antibody; Neurofilament 5 antibody; Neurofilament 66 antibody; Neurofilament 66 tax binding protein antibody; Neurofilament-66 antibody; NF 66 antibody; NF-66 antibody; NF66 antibody; TXBP 1 antibody; TXBP1 antibody
Species Reactivity
Human
Immunogen
A synthesized peptide derived from human INA
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone No.
7G11
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:200
Protocols
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

Alpha-internexin, encoded by the INA gene, is a neuronal intermediate filament protein that plays a fundamental role in the morphogenesis and maintenance of neurons. As a class IV intermediate filament expressed predominantly in the central nervous system, alpha-internexin serves as an early marker of neuronal differentiation and contributes to axonal caliber and structural integrity. Its expression patterns make it particularly valuable for investigating neurodevelopmental processes, neuronal identity, and pathological conditions affecting the nervous system, including certain brain tumors where neuronal markers inform diagnostic and research efforts.

This recombinant monoclonal antibody, clone 7G11, offers the reproducibility and consistency that demanding research applications require. Produced using recombinant technology in rabbit host, the antibody is sequence-defined, ensuring lot-to-lot uniformity that supports longitudinal studies and reproducible experimental workflows. The monoclonal nature guarantees specificity to a single epitope on the human INA protein, derived from a synthesized peptide immunogen.

Validation in immunohistochemistry demonstrates reliable performance in paraffin-embedded human glioma tissue, where the antibody successfully detected alpha-internexin at 1:100 dilution using a standard polymer-based HRP detection system with citrate buffer antigen retrieval. This validation in glioma samples is particularly relevant given the diagnostic and research interest in neuronal marker expression within brain tumors. The antibody is also validated for ELISA applications, with recommended IHC dilutions ranging from 1:50 to 1:200 to accommodate varying tissue types and detection systems.

Supplied in a stabilized liquid format with glycerol for convenient storage, this antibody serves researchers investigating neuronal biology, neurodegenerative diseases, and neuro-oncology applications.

Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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INA Antibodies

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Target Background

Function
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks.
Gene References into Functions
  1. Data suggest GRINL1A (GCOM1)-NMDA receptor-internexin-alpha (INA) interaction pathway may be relevant to neuroprotection. PMID: 29339073
  2. It is a neuronal marker, and has been indicated as an immunohistochemical surrogate of chromosome 1p/19q co-deletion in oligodendroglial tumors. PMID: 26233522
  3. Gonadotropinomas, null cell pituitary adenomas, and thyrotropinomas exhibit high levels of intracellular INA protein indicating neuronal transdifferentiation. PMID: 25236435
  4. It is a supportive diagnostic marker for oligodendroglial tumors with the 1p/19q co-deletion. PMID: 24197863
  5. alpha-Internexin was expressed in 53% of 350 pancreatic neuroendocrine tumors. Reduced expression of alpha-internexin was significantly associated with advanced stage metastases, recurrence and shorter overall survival. PMID: 24483152
  6. High INA expression is associated with grade II gliomas. PMID: 22890969
  7. INA may provide additional biologic information relevant to delineation of both pancreatic neuroendocrine neoplasms (NEN) tumor phenotypes and clinical behavior. PMID: 21990041
  8. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
  9. alpha-internexin expression in neuroblastoma PMID: 12209604
  10. The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in inclusion diseeae and other neurological diseases with pathological accumulations of IFs. PMID: 15161649
  11. Abnormal neuronal intermediate filament inclusions of alpha-internexin have been identified as the pathological hallmark of neuronal intermediate filament inclusion disease PMID: 16722980
  12. Expression of the 2 markers, alpha-internexin and peripherin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
  13. Alpha-Internexin (INA) expression appears to be a simple, reliable prognostic marker and a surrogate marker of 1p19q codeletion. PMID: 19139367

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Protein Families
Intermediate filament family
Tissue Specificity
Found predominantly in adult CNS.
Database Links

HGNC: 6057

OMIM: 605338

KEGG: hsa:9118

STRING: 9606.ENSP00000358865

UniGene: Hs.500916

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