INA Antibody

Code CSB-PA206018
Size US$297
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  • Western blot analysis of extracts from K562 cells, using INA antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INA Polyclonal antibody
Uniprot No.
Target Names
INA
Alternative Names
66 kDa neurofilament protein antibody; AINX_HUMAN antibody; Alpha Inx antibody; Alpha-internexin antibody; Alpha-Inx antibody; INA antibody; Internexin neuronal intermediate filament protein alpha antibody; MGC12702 antibody; NEF 5 antibody; NEF5 antibody; Neurofilament 5 (66kD) antibody; Neurofilament 5 antibody; Neurofilament 66 antibody; Neurofilament 66 tax binding protein antibody; Neurofilament-66 antibody; NF 66 antibody; NF-66 antibody; NF66 antibody; TXBP 1 antibody; TXBP1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from Internal of Human INA.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges. May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks.
Gene References into Functions
  1. Data suggest GRINL1A (GCOM1)-NMDA receptor-internexin-alpha (INA) interaction pathway may be relevant to neuroprotection. PMID: 29339073
  2. It is a neuronal marker, and has been indicated as an immunohistochemical surrogate of chromosome 1p/19q co-deletion in oligodendroglial tumors. PMID: 26233522
  3. Gonadotropinomas, null cell pituitary adenomas, and thyrotropinomas exhibit high levels of intracellular INA protein indicating neuronal transdifferentiation. PMID: 25236435
  4. It is a supportive diagnostic marker for oligodendroglial tumors with the 1p/19q co-deletion. PMID: 24197863
  5. alpha-Internexin was expressed in 53% of 350 pancreatic neuroendocrine tumors. Reduced expression of alpha-internexin was significantly associated with advanced stage metastases, recurrence and shorter overall survival. PMID: 24483152
  6. High INA expression is associated with grade II gliomas. PMID: 22890969
  7. INA may provide additional biologic information relevant to delineation of both pancreatic neuroendocrine neoplasms (NEN) tumor phenotypes and clinical behavior. PMID: 21990041
  8. the importance of alpha-internexin and NF-L in regulating the conformations of NF-M and NF-H PMID: 20213320
  9. alpha-internexin expression in neuroblastoma PMID: 12209604
  10. The discovery of alpha-internexin in the cytoplasmic inclusions implicates novel mechanisms of pathogenesis in inclusion diseeae and other neurological diseases with pathological accumulations of IFs. PMID: 15161649
  11. Abnormal neuronal intermediate filament inclusions of alpha-internexin have been identified as the pathological hallmark of neuronal intermediate filament inclusion disease PMID: 16722980
  12. Expression of the 2 markers, alpha-internexin and peripherin, in a small round cell tumor strongly favors the diagnosis of neuroblastoma. PMID: 18528283
  13. Alpha-Internexin (INA) expression appears to be a simple, reliable prognostic marker and a surrogate marker of 1p19q codeletion. PMID: 19139367

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Protein Families
Intermediate filament family
Tissue Specificity
Found predominantly in adult CNS.
Database Links

HGNC: 6057

OMIM: 605338

KEGG: hsa:9118

STRING: 9606.ENSP00000358865

UniGene: Hs.500916

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