Code | CSB-RA155156A0HU |
Size | US$210 |
Order now | |
Image |
|
Have Questions? | Leave a Message or Start an on-line Chat |
Application | Recommended Dilution |
---|---|
IF | 1:20-1:200 |
The production of the INSR recombinant monoclonal antibody involves four main steps: sequencing the INSR monoclonal antibody gene, cloning the gene into a plasmid vector, transfecting the recombinant vector into a host cell line, and finally purifying the INSR recombinant monoclonal antibody from the cell culture supernatant using affinity chromatography. The INSR monoclonal antibody is generated from INSR antibody-producing hybridomas, and a human INSR-derived peptide is used as an immunogen during the INSR monoclonal antibody production. This INSR recombinant antibody is suitable for use in ELISA and IF assays to detect human INSR protein.
The INSR protein plays a critical role in regulating glucose homeostasis in cells. It is a transmembrane receptor that binds insulin, triggering a signaling cascade that promotes glucose uptake and storage in peripheral tissues such as muscle, fat, and liver. The INSR protein is expressed in many different types of cells, but its most important functions are in the regulation of glucose metabolism in adipocytes, hepatocytes, and myocytes. Dysregulation of the INSR protein can lead to insulin resistance, a condition in which the body's tissues become less responsive to insulin, which is a hallmark of type 2 diabetes.
There are currently no reviews for this product.