Code | CSB-RA548303A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
The ITGAV recombinant monoclonal antibody was prepared by protein technology and DNA recombinant technology. Initially, a synthesized peptide derived from human ITGAV was used to immunize mice. After a period of time, the spleen was removed from the mice under aseptic conditions, and the total RNA of the spleen cells was extracted. The cDNA synthesized by RNA reverse transcription was used as a template for PCR amplification of the ITGAV antibody gene. The gene was then introduced into a vector and transfected into host cells for culture. The ITGAV recombinant monoclonal antibody was purified from the supernatant of the cell culture by affinity chromatography. It was thoroughly verified and can be used in ELISA and IHC experiments to detect human ITGAV protein.
The ITGAV protein is a transmembrane receptor protein that is involved in cell adhesion, migration, proliferation, and survival. Upon ligand binding, ITGAV triggers intracellular signaling pathways that regulate cellular responses such as cytoskeletal rearrangements, gene expression, and cell proliferation. It plays a crucial role in development, wound healing, and angiogenesis, and is implicated in the pathogenesis of several diseases, including cancer, cardiovascular disease, and inflammatory disorders.
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