ITGAV

Integrin alpha-V (ITGAV), also known as CD51 or VTNR, is a transmembrane receptor that primarily pairs with β-subunits (e.g., β3, β5, β6) to form heterodimeric complexes. These complexes bind extracellular matrix (ECM) ligands such as fibronectin and vitronectin, facilitating cell adhesion, migration, and bidirectional signaling. ITGAV is critical in pathological processes like tumor angiogenesis, epithelial-mesenchymal transition (EMT), and fibrosis. Dysregulation of ITGAV is implicated in aggressive cancers (e.g., glioblastoma, breast cancer), chronic fibrotic disorders (e.g., liver cirrhosis), and osteoporosis, often correlating with poor prognosis.
Targeting ITGAV has emerged as a therapeutic strategy. The cyclic RGD peptide Cilengitide, an αvβ3/αvβ5 integrin antagonist, advanced to Phase III trials for glioblastoma but failed to meet efficacy endpoints. Current efforts focus on antibody-drug conjugates (ADCs) and small-molecule inhibitors to block ITGAV-mediated TGF-β activation or ECM remodeling. Preclinical models highlight synergies with immune checkpoint inhibitors, while novel αvβ6-specific agents show promise in treating pulmonary fibrosis. Challenges remain in optimizing selectivity and overcoming compensatory pathways in clinical translation.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Human TGFB1 (CSB-MP023446HU(A4)c9). The EC₅₀ is 8.576-10.18 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Anti-ITGB6 recombinant antibody (CSB-RA011890MA1HU). The EC₅₀ is 7.021-9.054 ng/mL.

The purity of ITGAV&ITGB6 was greater than 90% as determined by SEC-HPLC

ITGAV Recombinant Monoclonal Antibody (CSB-RA279866A0HU)

Validated Data

Western Blot
Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
All lanes: ITGAV antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 113, 112 kDa
Observed band size: 130 kDa

IHC image of CSB-RA279866A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following ITGAV reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ITGAV Antibodies

ITGAV Proteins

ITGAV Antibodies

ITGAV Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA000074	Cleaved-ITGAV (K889) Antibody	Human	WB, ELISA
CSB-PA003047	ITGAV Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA011877LA01HU	ITGAV Antibody	Human	ELISA, WB, IHC, IF
CSB-PA011877LB01HU	ITGAV Antibody, HRP conjugated	Human	ELISA
CSB-PA011877LC01HU	ITGAV Antibody, FITC conjugated	Human
CSB-PA011877LD01HU	ITGAV Antibody, Biotin conjugated	Human	ELISA
CSB-RA548303A0HU	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-RA279866A0HU	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA011877MA1HU	ITGAV Recombinant Monoclonal Antibody	Human, Mouse	ELISA, IF, FC

ITGAV Proteins

ITGAV Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP011877BO CSB-EP011877BO CSB-BP011877BO CSB-MP011877BO CSB-EP011877BO-B	Recombinant Bovine Integrin alpha-V (ITGAV), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGAV Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP011877MO CSB-EP011877MO CSB-BP011877MO CSB-EP011877MO-B	Recombinant Mouse Integrin alpha-V (Itgav), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

ITGAV Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP011877CH CSB-EP011877CH CSB-BP011877CH CSB-MP011877CH CSB-EP011877CH-B	Recombinant Chicken Integrin alpha-V (ITGAV), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ITGAV Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP011877HU	Recombinant Human Integrin alpha-V (ITGAV), partial	Yeast
CSB-EP011877HU CSB-BP011877HU CSB-EP011877HU-B	Recombinant Human Integrin alpha-V (ITGAV), partial	E.coli Baculovirus In Vivo Biotinylation in E.coli

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ITGAV

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