Code | CSB-RA279866A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The production process of the ITGAV recombinant monoclonal antibody comprises four steps: sequencing the gene that codes for the ITGAV monoclonal antibody, cloning the gene into a plasmid vector, transfecting the recombinant vector into a host cell line, purifying the ITGAV recombinant monoclonal antibody from the cell culture supernatant using affinity chromatography, and testing and characterizing the purified antibody. The ITGAV monoclonal antibody is produced from hybridomas that produce the ITGAV antibody. To produce the ITGAV monoclonal antibody, a synthesized peptide derived from human ITGAV is used as the immunogen. This ITGAV recombinant monoclonal antibody is recommended for ELISA, WB, and IHC applications in detecting human ITGAV protein.
The ITGAV protein is a transmembrane protein that plays a role in cell adhesion and signaling. It forms heterodimers with other integrin subunits, such as Integrin beta-1, to bind to extracellular matrix proteins, such as fibronectin and vitronectin, and modulate cell behavior. Specifically, ITGAV is involved in regulating cell migration, proliferation, differentiation, and survival, as well as angiogenesis and wound healing. Dysregulation of ITGAV has been linked to various diseases, including cancer, osteoporosis, and autoimmune disorders.
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