Code | CSB-RA621519A1HU |
Size | US$210 |
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To produce the MERTK recombinant monoclonal antibody, the MERTK monoclonal antibody gene is first sequenced, and the gene is then cloned into a plasmid vector. Next, the recombinant vector is transfected into a host cell line, and the MERTK recombinant monoclonal antibody is purified from the cell culture supernatant through affinity chromatography. Finally, the purified antibody is tested and characterized. The MERTK monoclonal antibody is generated from MERTK antibody-producing hybridomas, with a recombinant human MERTK protein being used as the immunogen during production. This MERTK recombinant monoclonal antibody is recommended for use in detecting human MERTK protein in ELISA.
MERTK mainly regulates various cellular processes such as cell proliferation, differentiation, survival, and phagocytosis of apoptotic cells. Specifically, MERTK plays a crucial role in the clearance of apoptotic cells by promoting phagocytosis, which is important for the maintenance of tissue homeostasis and the prevention of autoimmune diseases. Additionally, MERTK is involved in the regulation of innate immune responses, including the production of cytokines and chemokines. Dysregulation of MERTK has been linked to various diseases, such as cancer, inflammation, and autoimmune disorders.
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