Code | CSB-RA010418A128me1HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:2000 |
The mono-methyl-histone H3.1 (R128) recombinant monoclonal antibody production process initiates with the cloning of genes responsible for encoding the HIST1H3A antibody, covering both heavy and light chains. These cloned genes are integrated into expression vectors, which are introduced into host cells via transfection. The host cells assume the task of producing and secreting the antibody. After purification through affinity chromatography to guarantee its purity, the antibody undergoes comprehensive functionality testing in ELISA and WB applications, ensuring accurate detection of the human and mouse HIST1H3A proteins mono-methylated at R128.
Histone H3.1 mono-methylation at arginine 128 (R128) may promote transcriptional activation or repression depending on the context and the specific proteins involved. H3.1 R128 mono-methylation can serve as an epigenetic signal, indicating specific chromatin states and influencing cellular processes such as differentiation, development, and cellular identity.
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