Code | CSB-RA579492A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
Through the utilization of in vitro expression systems, the NAIP recombinant monoclonal antibody is synthesized by cloning DNA sequences of NAIP antibodies from immunoreactive rabbits. The immunogen employed in this process is a synthesized peptide derived from the human NAIP protein. Subsequently, the genes encoding the NAIP antibodies are inserted into plasmid vectors, and these recombinant plasmid vectors are then transfected into host cells to enable antibody expression. The NAIP recombinant monoclonal antibody undergoes affinity-chromatography purification and is thoroughly tested for functionality in ELISA and IHC applications, displaying reactivity with the human NAIP protein during these evaluations.
NAIP is an important protein involved in the detection of intracellular bacterial pathogens and the initiation of an immune response through the activation of the NLRC4 inflammasome. Its role is essential in the host's defense against infections caused by bacteria that use type III secretion systems to manipulate host cells.
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