Code | CSB-RA232619A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
OGT, a conserved O-GlcNAc transferase, modifies the function, stability, and localization of intracellular proteins by O-GlcNAcylation of their serine and threonine residues. OGT and OGA work together to maintain cellular O-GlcNAc homeostasis, which is crucial for a range of cellular functions such as metabolism, stress responses, and proteostasis. The mammalian cell cycle regulator host cell factor C1 is proteolytically cleaved and activated by OGT (HCF-1). In C. elegans GABA neurons, it also has non-catalytic activities in epithelial adherence junctions and an EEl-1-dependent E3 ubiquitin ligase complex. In most metazoans, knocking down OGT is lethal at either the single-cell or developmental level.
The recombinant OGT antibody is a monoclonal antibody molecule expressed by using recombinant DNA and protein engineering technology to clone the genes encoding the OGT antibody into a plasma vector and then by transfecting the vector clone into the appropriate recipient mammalian cells for production. It was purified using Affinity-chromatography. And it shows reactivity with OGT protein from Human, Mouse, Rat. This recombinant OGT antibody can be used in the ELISA, WB, IHC.There are currently no reviews for this product.