Code | CSB-RA009962A216phHU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
Phospho-GSK3A/GSK3B (Y216 + Y279) antibody CSB-RA009962A216phHU is a recombinant monoclonal antibody belonging to rabbit IgG. Its production procedures include: the acquisition of the anti-GSK3 Beta-pY216 + GSK3 Alpha-pY279 monoclonal antibody using the synthesized peptide derived from the human phospho-GSK3A/GSK3B (Y216 + Y279) immunizes animals; the determination of DNA sequence of the monoclonal antibody; the clone of the DNA sequence into the plasmid and subsequent transfection into cell lines for expression. This phospho-GSK3A/GSK3B (Y216 + Y279) antibody underwent purification using affinity-chromatography. It has been tested in ELISA and IHC. It is reactive with the human phospho-GSK3A/GSK3B (Y216 + Y279) protein.
All eukaryotes have GSK3, which is a versatile serine/threonine kinase. GSK3 is engaged in a wide range of cellular functions, from glycogen metabolism to cell cycle regulation and proliferation, and is a crucial regulator of numerous signaling pathways, including cellular responses to Wnt, receptor tyrosine kinases, and G protein-coupled receptors. GSK3α and GSK3β are two GSK-3 isoforms. GSK3 kinase activity is activated by phosphorylation on tyrosine residues (GSK3 Y279 and GSK3 Y216).
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