Code | CSB-RA859108A463phHU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
This phosphorylated SMAD5 antibody CSB-RA859108A463phHU is a recombinant monoclonal antibody produced from the expression of the plasmids that were integrated by the phospho-SMAD5 (S463+S465) monoclonal antibody DNA sequence in cell lines. The phospho-SMAD5 (S463+S465) monoclonal antibody was generated from splenocytes isolated from the animals that were immunized with the human phospho-SMAD5 (S463+S465). The phospho-SMAD5 (S463+S465) recombinant antibody is a rabbit IgG antibody. It underwent purification using the affinity-chromatography method. It can detect the human phospho-SMAD5 (S463+S465). And it is suitable for ELISA and IHC analyses.
SMAD5 is a receptor-activated Smad that serves as an intracellular signal transducer for the transforming growth factor (TGF) superfamily. SMAD5 regulates cytoplasmic metabolic machinery and works as an intracellular pH messenger to maintain cell bioenergetic balance. SMAD5 is a negative regulator of embryonic hematopoiesis in a haploinsufficiency form, according to a recent study by Bing Liu et al., which helps to understand the cytogenetic mechanism by which SMAD5 serves as a leukemia suppressor.
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