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The SLC7A11 recombinant monoclonal antibody is obtained by constructing the SLC7A11 antibody genes into plasmid vectors and then transfecting the constructed plasmid vectors into suitable host cells for expression through exogenous protein expression technology. This SLC7A11 recombinant monoclonal antibody underwent affinity-chromatography purification and was validated for ELISA. In the functional ELISA, the human SLC7A11 protein (CSB-CF892171HU(A4)) at 2 μg/mL can bind this SLC7A11 recombinant monoclonal antibody, with the EC50of 9.452-13.79 ng/mL.
SLC7A11 is a component of a heterodimeric amino acid transporter known as system xCT, which consists of SLC7A11 and SLC3A2. SLC7A11 functions as the light chain subunit of this transporter. The primary role of SLC7A11 is to exchange cystine for glutamate, across the cell membrane. It also regulates redox balance.
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