Code | CSB-RA883439MA1HU |
Size | US$210 |
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The production of the TMEFF2 monoclonal antibody involved using the recombinant human TMEFF2 protein as the immunogen. The cDNA of the TMEFF2 monoclonal antibody was sequenced and obtained the TMEFF2 monoclonal antibody gene, which was then cloned into a plasmid vector. The plasmid vector carrying the TMEFF2 monoclonal antibody gene was transfected into the host cell using a suitable transfection method. The resulting TMEFF2 recombinant monoclonal antibody was then subjected to affinity-chromatography purification. Its specificity was confirmed through ELISA, where it showed binding to the recombinant human TMEFF2 (CSB-MP883439HU) with an EC50 range of 2.129-2.956 ng/mL. It can react with TMEFF2 protein.
TMEFF2 is expressed in several tissues, including the brain, lung, prostate, and breast. TMEFF2 mainly functions as a tumor suppressor, as it has been shown to inhibit cell proliferation and induce apoptosis in certain types of cancer cells, including prostate and breast cancer. TMEFF2 has also been suggested to have a role in neuronal differentiation and migration during brain development, and may be involved in the regulation of synaptic transmission.
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