Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-RA902876A0HU |
| Size |
US$350Purchase it in Cusabio online store (only available for customers from the US) |
| Image |
|
| Have Questions? | Leave a Message or Start an on-line Chat |
| Description |
The TPBG recombinant monoclonal antibody is a highly specific anti-TPBG antibody. This TPBG antibody was produced by inserting the DNA sequence encoding the TPBG monoclonal antibody into plasmids and then transfecting the plasmids into cell lines for expression. Its isotype is identical to rabbit IgG. This TPBG antibody detects the TPBG protein in human and mouse samples and can be used in ELISA, WB, and IHC. TPBG, an oncofetal antigen, is low expressed in normal tissues but upregulated in a variety of human cancers. High expression of TPBG usually indicates a poor clinical outcome. Jeong-Eun Yoo et. al has found that TPBG is an efficient sorting marker for ventral mesencephalic dopaminergic precursors originated from human pluripotent stem cells. |
||||||
| Uniprot No. | Q13641 | ||||||
| Target Names | TPBG | ||||||
| Alternative Names | Trophoblast glycoprotein (5T4 oncofetal antigen) (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (M6P1) (Wnt-activated inhibitory factor 1) (WAIF1), TPBG, 5T4 | ||||||
| Species Reactivity | Human, Mouse | ||||||
| Immunogen | A synthesized peptide derived from human 5T4 | ||||||
| Immunogen Species | Homo sapiens (Human) | ||||||
| Conjugate | Non-conjugated | ||||||
| Clonality | Monoclonal | ||||||
| Isotype | Rabbit IgG | ||||||
| Clone No. | 6E9 | ||||||
| Purification Method | Affinity-chromatography | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | ||||||
| Form | Liquid | ||||||
| Tested Applications | ELISA, WB, IHC | ||||||
| Recommended Dilution |
|
||||||
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
||||||
| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
There are currently no reviews for this product.
| Function |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
|
| Gene References into Functions |
|
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma. |
| Database Links |
HGNC: 12004 OMIM: 190920 KEGG: hsa:7162 STRING: 9606.ENSP00000358765 UniGene: Hs.71947 |
