Code | CSB-RA025141A1HU |
Size | US$210 |
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To produce the TSLP recombinant monoclonal antibody, a complex process is followed that involves several stages. Firstly, the TSLP monoclonal antibody is obtained and its gene sequence is determined. Next, a vector containing the TSLP monoclonal antibody gene is constructed and transfected into a host cell line for culturing. To synthesize the TSLP monoclonal antibody, a recombinant human TSLP protein is used as an immunogen. The resulting TSLP recombinant monoclonal antibody is then purified via affinity chromatography and evaluated for specificity using ELISA. It only reacts with human TSLP protein.
TSLP is a cytokine produced by epithelial cells, including those in the skin, lung, and intestine. It functions as a key regulator of innate and adaptive immune responses. TSLP is involved in promoting allergic inflammation, regulating immune tolerance, and maintaining homeostasis in epithelial tissues. TSLP stimulates dendritic cells to differentiate into a subtype that produces a type 2 cytokine profile. This results in the activation of CD4+ T cells, particularly T helper 2 (Th2) cells, which produce cytokines such as IL-4, IL-5, and IL-13, promoting the differentiation of B cells into plasma cells that secrete IgE. TSLP also promotes the differentiation of regulatory T cells (Tregs), which can suppress immune responses.
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