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| Code | CSB-CF023451BO |
| Product Type | Transmembrane Protein |
| Size | Pls inquiry other sizes |
| Uniprot No. | O46680 |
| Storage Buffer | Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
| Species | Bos taurus (Bovine) |
| Sequence | LQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSITTTYCCNQDHCNKIELPTVGKPSSGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEVARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM |
| Source | in vitro E.coli expression system |
| Gene Names | TGFBR1 |
| Protein Names | Recommended name: TGF-beta receptor type-1 Short name= TGFR-1 EC= 2.7.11.30 Alternative name(s): TGF-beta type I receptor Transforming growth factor-beta receptor type I Short name= TGF-beta receptor type I Short name= TbetaR-I |
| Expression Region | 30-499 |
| Tag Info | N-terminal 10xHis-tagged |
| Protein Description | Full Length of Mature Protein |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). |
| Subcellular Location | Cell membrane, Single-pass type I membrane protein, Cell junction, tight junction, Membrane raft, Cell surface |
| Protein Families | Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily |
| Database Links |
KEGG: bta:282382 STRING: 9913.ENSBTAP00000024010 UniGene: Bt.91785 |
| Pathway |
Hippo signaling pathway
MAPK signaling pathway TGF-beta signaling pathway Adherens junction Cellular senescence Osteoclast differentiation Th17 cell differentiation AGE-RAGE signaling pathway in diabetic complications Apelin signaling pathway FoxO signaling pathway Endocytosis |
TGFBR1 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP023451BO1 CSB-EP023451BO1 CSB-BP023451BO1 CSB-MP023451BO1 |
Recombinant Bovine TGF-beta receptor type-1(TGFBR1),partial | Yeast E.coli Baculovirus Mammalian cell |
Recombinant Legionella pneumophila Peptidoglycan-associated lipoprotein(pal)
Express system: E.coli
Species: Legionella pneumophila
Recombinant Staphylococcus aureus Acyl carrier protein(acpP)
Express system: Yeast
Species: Staphylococcus aureus (strain Mu50 / ATCC 700699)
Recombinant Candida glabrata Serine/threonine-protein kinase ATG1(ATG1),partial
Express system: E.coli
Species: Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Recombinant Human Cyclic AMP-dependent transcription factor ATF-7(ATF7)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Interleukin-2 receptor subunit beta(Il2rb),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Protein-lysine 6-oxidase(LOX)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Rat Beta-nerve growth factor(Ngf)
Express system: Yeast
Species: Rattus norvegicus (Rat)
