Recombinant Human B2 bradykinin receptor(BDKRB2)

Code CSB-CF002652HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names BDKRB2
Uniprot No. P30411
Alternative Names B2; B2 bradykinin receptor; B2BKR; B2BRA; B2R; BDKR B2; BDKRB 2; BDKRB2; BK 2; BK 2 receptor; BK R2; BK-2 receptor; BK2; BK2 receptor; BK2R; BKR 2; BKR2; BKRB2_HUMAN; BR B2; Bradykinin receptor B2; Bradykinin receptor beta 2; BRB 2; BRB2; DKFZp686O088; Kinin B2
Species Homo sapiens (Human)
Expression Region 1-391
Target Protein Sequence MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Gene References into Functions
  1. Study results indicated that the bradykinin B2 receptor-mediated pathway is involved in the cPLA2-related inflammatory response from the PKC pathway in traumatic brain injury. PMID: 29894755
  2. The most characteristic signaling pathways for B2R and D2R, dependent on intracellular Ca(2+) and cAMP concentration, respectively, were analyzed in cells presenting similar endogenous expression of B2R and D2R.The evidence of B2R-D2R dimerization may open new perspectives in the modulation of diverse cellular functions which depend on their activation. PMID: 28757212
  3. These results indicate that KOR can form a heterodimer with B2R and this leads to increased protein kinase A activity by the CREB signaling pathway, leading to a significant increase in cell proliferation. PMID: 28069442
  4. Study demonstrated the ability of long-chain polyunsaturated fatty acids to act as agonist to the B2R at nanomolar concentrations and to induce receptor conformational changes. PMID: 23826374
  5. Data suggest that N-myc (and STAT) interactor (NMI) could improve its downstream target bradykinin B2 receptor (BDKRB2) expression to induce extracellular signal-regulated kinases (ERK) 1/2 activation, and thereby further evoke malignant progression of hepatocellular carcinoma (HCC). PMID: 28077802
  6. BDKRB2 +9/-9 bp polymorphisms affected the gene expression and nitric oxide production, which were associated with radiographic severity of osteoarthritis, suggesting that the BDKRB2 +9/ -9 bp polymorphisms may act as a genetic modulator of osteoarthritis, and play an essential role in inflammatory process in osteoarthritis. PMID: 26764266
  7. Review/Meta-analysis: suggest bradykinin B2 receptor -58C allele and -58CC genotype increase the risk of hypertension in Asians and African-Americans. Inversely, -58TT genotype decreases the risk of hypertension in Asians and African-Americans. PMID: 27007662
  8. authors found significant interactions among PRKCA, NOS3 and BDKRB2 genotypes associated with enalapril responses. PMID: 27696692
  9. Bronchial B2R expression is constitutively elevated in allergic asthma and is further increased after allergen exposure together with NF-kB expression. PMID: 26588817
  10. Report the presence of nuclear B2R in the utero-placental unit and reduced abundance of nuclear B2R in extravillous trophoblast in preeclampsia. PMID: 26955769
  11. Data provide evidence that the BDKRB2 +9/-9 polymorphisms influence pro-inflammatory cytokine levels in knee osteoarthritis by altering TLR-2 expression. PMID: 26982743
  12. These results suggest that the response to long-term exercise training could be modulated by the BDKRB2 gene -9/+9 polymorphism in male athletes. In well-trained swimmers, BDKRB2 gene variation was not found to be an independent determinant of swimming performance. PMID: 26907838
  13. Significant association between the -58T/C polymorphism and the increased risk of Hypertension was found in Northern Han Chinese population. PMID: 26362411
  14. Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways. PMID: 26360782
  15. Bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects bradykinin activity. PMID: 25641172
  16. These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness. PMID: 25713410
  17. The nasal mucosa specimens from chronic rhinosinusitis patients expressed relatively higher B2R and slightly higher kininogen (KNG)/BK and B1R. PMID: 25970620
  18. A cross-talk was found between bradykinin B2 receptor and cytokines in retinal pigment epithelium. PMID: 26235941
  19. no association between the -9/+9 polymorphism and elite athletic status PMID: 25078958
  20. Genetic variation was observed in obese patients with hypertension, obese patients' total cholesterol levels varied by genotype, and waist circumference and blood pressure were elevated in the non-obese having a C/C genotype compared to T/C and T/T. PMID: 25529519
  21. Bradykinin receptor B2-VNTR length polymorphism was not associated with angina pectoris and myocardial infarction in Russian men. PMID: 25842860
  22. Bradykinin increases IL-6 production via B2R and the ERK pathway, thereby contributing to the invasion and migration of colorectal cancer cells. PMID: 25109623
  23. B2 receptor-mediated relaxation reduced in myometrial vessels in pre-eclampsia PMID: 24304135
  24. We propose that heterodimerization of bradykinin B2 receptor with lamin C is essential to nuclear localization of bradykinin B2 receptor and plays an important role in cell signaling and function. PMID: 24211782
  25. Bradykinin activates multiple signal transduction pathways in human trabecular meshwork cells via B2-receptors that also mediate intraocular pressure reduction PMID: 24236827
  26. These results suggest that reflex muscle vasodilation and ACE activity in response to exercise training are modulated by BDKRB gene +9/-9 polymorphism in healthy individuals. PMID: 23613132
  27. Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors PMID: 24047499
  28. Bradykinin induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways. PMID: 23588115
  29. Our data suggest that the B -9 allele and reduced ACE activity are associated with both ACE-AE and ACE-cough. PMID: 23730990
  30. Dominant negative (GDP-locked)-Rab5 and -Rab11 reproduced the effects of inhibitors of tubulin and actin, respectively, on the cycling of bradykinin B receptor. PMID: 23454239
  31. These studies have provided evidence of a functional endogenously expressed B-receptor system in the ciliary muscle that appears to be involved in modulating intraocular pressure. PMID: 23805043
  32. there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals PMID: 23362199
  33. Triceps brachii morphological response to targeted strength training--hypertrophy--is related to bradykinin type (BK)2 receptor polymorphisms. PMID: 23127247
  34. Our findings suggest that both eNOS and bradykinin B2 receptor genotypes may affect the antihypertensive responses to enalapril. PMID: 22706620
  35. In coronary artery disease patients, bradykinin-B2-receptor downregulation on endothelial repair-promoting circulating mononuclear cells substantially impairs bradykinin-dependent endothelial repair. PMID: 23275384
  36. results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/-9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance PMID: 23176367
  37. Suggest that the BDKRB2 +9/-9 polymorphism may act as a genetic modulator of glucose homeostasis and increase susceptibility to diabetes. PMID: 23243416
  38. Bradykinin up-regulates B(2) receptor expression (P<0.05) and stimulate IL-8 release (P<0.001) in BEAS-2B cells. PMID: 22935637
  39. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. PMID: 23132855
  40. The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH. PMID: 22900090
  41. Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCdelta/c-Src dependent signaling pathway. PMID: 22653778
  42. The +9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA. PMID: 23093849
  43. expression showed a growing trend with grade of endometrial cancer, reaching the peak in grade 2, whereas grade 3 was characterized by a decrease in transcriptional activity PMID: 22706224
  44. Maximakinin is an agonist of the human and rabbit B(2)R with a 8-12 fold lesser potency. PMID: 22108573
  45. While -58C>T polymorphism did not reveal any association with essential hypertension, +/-9 bp polymorphism showed a significant association with high risk for heterozygotes (+9/-9) when tested against the pooled frequencies of homozygotes. PMID: 22468762
  46. Capillary electrophoresis is a rapid, accurate and sensitive method for genotyping the 9-bp exon 1 insertion/deletion polymorphism in BDKRB2. PMID: 22304584
  47. Tested the influence of the interaction between the BDKRB2 -9/+9 and the GNB3 C825T (rs5443) genotypes in relation to endurance performance. There was no interaction between BDKRB2 -9/+9 and GNB3 C825T polymorphisms in relation to endurance. PMID: 21210858
  48. Results demonstrate that helix 8 of the B(2)R plays a crucial role not only in efficient trafficking to the plasma membrane or the activation of G proteins but also for the interaction of the B(2)R with GRK2/3 and beta-arrestins. PMID: 22016392
  49. Aging cardiac endothelial cells gradually lose their capacity to express BK-2Rs. PMID: 21986469
  50. High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. PMID: 21586566

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB2 sub-subfamily
Tissue Specificity Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
Database Links

HGNC: 1030

OMIM: 113503

KEGG: hsa:624

STRING: 9606.ENSP00000307713

UniGene: Hs.654542

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