Recombinant Human Interleukin-7 receptor subunit alpha(IL7R)

Code CSB-CF011670HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P16871
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence ESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNTTNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVIYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSGEMDPILLTISILSFFSVALLVILACVLWKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ
Source in vitro E.coli expression system
Gene Names IL7R
Protein Names Recommended name: Interleukin-7 receptor subunit alpha Short name= IL-7 receptor subunit alpha Short name= IL-7R subunit alpha Short name= IL-7R-alpha Short name= IL-7RA Alternative name(s): CDw127 CD_antigen= CD127
Expression Region 21-459
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis 3 (MS3)
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 3: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 4: Secreted
Protein Families Type I cytokine receptor family, Type 4 subfamily
Database Links

HGNC: 6024

OMIM: 146661

KEGG: hsa:3575

STRING: 9606.ENSP00000306157

UniGene: Hs.591742

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Hematopoietic cell lineage
FoxO signaling pathway

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