Recombinant Human Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB(MAN1A2)

Code CSB-CF013384HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O60476
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHWVFNTEAHPLPVLHLANTTLSGNPAVR
Source in vitro E.coli expression system
Gene Names MAN1A2
Protein Names Recommended name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB EC= 3.2.1.113 Alternative name(s): Mannosidase alpha class 1A member 2 Processing alpha-1,2-mannosidase IB Short name= Alpha-1,2-mannosidase IB
Expression Region 1-641
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyl hydrolase 47 family
Tissue Specificity Highest levels of expression in placenta and testis.
Database Links

HGNC: 6822

OMIM: 604345

KEGG: hsa:10905

STRING: 9606.ENSP00000348959

UniGene: Hs.435938

Pathway Protein processing in endoplasmic reticulum

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