Recombinant Human Receptor activity-modifying protein 3(RAMP3)

Code CSB-CF019306HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O60896
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence RAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL
Source in vitro E.coli expression system
Gene Names RAMP3
Protein Names Recommended name: Receptor activity-modifying protein 3 Alternative name(s): Calcitonin-receptor-like receptor activity-modifying protein 3 Short name= CRLR activity-modifying protein 3
Expression Region 24-148
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Subcellular Location Cell membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein
Protein Families RAMP family
Tissue Specificity Strongly expressed in lung, breast, immune system and fetal tissues.
Database Links

HGNC: 9845

OMIM: 605155

KEGG: hsa:10268

STRING: 9606.ENSP00000242249

UniGene: Hs.25691

Pathway Vascular smooth muscle contraction

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