RAMP3 Antibody

Code CSB-PA019306GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
RAMP3
Alternative Names
RAMP3; Receptor activity-modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human RAMP3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Gene References into Functions
  1. The expression of RAMP3 is downregulated in the fetal lung with increasing gestational age. PMID: 24169318
  2. the RAMP3 TMD participates in the negative regulation of CLR/RAMP3 internalization. PMID: 22445753
  3. Data show that LOXL2 and RAMP3 are strongly coexpressed in human colon, breast, and gastric carcinomas but not in normal colon or gastric epithelial cells. PMID: 20802105
  4. This study provides insight into the role of three amino acid changes in human RAMP3. PMID: 20034525
  5. Morphological fluorescence techniques, bioluminescence resonance energy transfer, and bimolecular fluorescence complementation analysis demonstrate that the secretin receptor associates specifically with RAMP3, but not with RAMP1 or RAMP2. PMID: 19886671
  6. RAMP3 interacts with N-ethylmaleimide-sensitive factor to cause the change in trafficking PMID: 15613468
  7. results, using both endogenous and overexpressed cellular models, indicate a novel function for NHERF-1 and RAMP3 in the internalization of the adrenomedullin receptor and suggest additional regulatory mechanisms for receptor trafficking PMID: 15805108
  8. Identification of RAMP3 residues for adrenomedjullin receptors are reported. PMID: 18593822

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
Protein Families
RAMP family
Tissue Specificity
Strongly expressed in lung, breast, immune system and fetal tissues.
Database Links

HGNC: 9845

OMIM: 605155

KEGG: hsa:10268

STRING: 9606.ENSP00000242249

UniGene: Hs.25691

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