Recombinant Human Tetraspanin-7 (TSPAN7)

Code CSB-CF025165HU(A4)
Abbreviation Recombinant Human TSPAN7 protein
MSDS
Size
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Target Names
TSPAN7
Uniprot No.
Research Area
Immunology
Alternative Names
Cell surface glycoprotein A15;Membrane component chromosome X surface marker 1;T-cell acute lymphoblastic leukemia-associated antigen 1;Transmembrane 4 superfamily member 2
Species
Homo sapiens (Human)
Source
in vitro E.coli expression system
Expression Region
1-249aa
Target Protein Sequence
MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Mol. Weight
30.6 kDa
Protein Length
Full Length
Tag Info
C-terminal 10xHis-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Function
May be involved in cell proliferation and cell motility.
Gene References into Functions
  1. These results disclosed a previously uncharacterized role of TSPAN7 in the regulation of the expression and functional activity of DRD2 by postendocytic trafficking. PMID: 28223337
  2. The role of TSPAN7 in immune system response to HIV-1 is reviewed. TSPAN7 appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes. PMID: 28620031
  3. Elevated TSPAN7 may be associated with better outcomes for multiple myeloma patients. PMID: 25637218
  4. Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma. PMID: 22213152
  5. This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 and ampa receptor trafficking. PMID: 22445342
  6. TM4SF2 was identified as a putative antigenic target in Wegener's granulomatosis PMID: 20951001
  7. Studies indicate that The thymus leukemia (TL) antigen and CD8alphaalpha are interacting surface molecules that are expressed at the frontline of the mucosal immune system. PMID: 20850477
  8. The interaction of VP26 with tetraspanin-7 plays an essential role in normal HSV-1 replication. PMID: 20630051
  9. associated with spermatozoa PMID: 19535787
  10. The role of TMSF2 in mental retardation PMID: 14735593
  11. coding mutations in TSPAN7 are not associated with our cohort of autism patients PMID: 19339915

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Involvement in disease
Mental retardation, X-linked 58 (MRX58)
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Tetraspanin (TM4SF) family
Tissue Specificity
Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
Database Links

HGNC: 11854

OMIM: 300096

KEGG: hsa:7102

STRING: 9606.ENSP00000367743

UniGene: Hs.441664

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