Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein(TNFRSF13C) (Active)

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Code CSB-AP002181HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q96RJ3
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered 20 mM PB, pH 8.0, 500 mM NaCl ,lyophilized
Alias B-cell-activating factor receptor, BAFF-R, BLyS receptor 3, CD antigen CD268
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 ug/ml in the presence of 1.0 μg/ml of rHuBAFF.
Purity >95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source E.coli
Gene Names TNFRSF13C
Expression Region 1-76aa
Tag Info Tag-Free
Mol. Weight 7.8 kDa
Protein Description Partial
PubMed ID 11509692; 10591208; 11591325; 12387744; 12755599; 12721620; 12715002; 16840730; 16160919; 19666484
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Function B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Involvement in disease Immunodeficiency, common variable, 4 (CVID4)
Subcellular Location Membrane, Single-pass type III membrane protein
Tissue Specificity Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Database Links

HGNC: 17755

OMIM: 606269

KEGG: hsa:115650

STRING: 9606.ENSP00000291232

UniGene: Hs.344088

Pathway NF-kappa B signaling pathway

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