CUSABIO Monthly Citation Review: 240 New Product Citations in July, Total Citations Hit 27,000!

Pg, a periodontal pathogen, degrades FOXO3 via LPS and gingipains, derepressing MSR1 to drive ox-LDL uptake and ROS production in macrophages, triggering necroptosis and expanding the necrotic core in atherosclerotic plaques. Antioxidants or MSR1 inhibition mitigate plaque instability.

R9AP is identified as a common receptor for EBV entry into both epithelial and B cells, binding the viral gH/gL complex to trigger membrane fusion. R9AP depletion, blocking peptides or monoclonal antibodies potently inhibit infection, highlighting its potential as a vaccine and antiviral target.

ATRX loss dismantles colonic epithelial identity via HNF4A inactivation, unlocking plastic mesenchymal and squamous-like states that fuel metastasis; human data confirm squamous signatures predict aggressive disease and poor outcome.

This study captures the fusion intermediates of SARS-CoV-2 with ACE2 using cryo-ET, revealing the entire process from receptor binding to complete fusion. The S protein undergoes extensive structural rearrangements, progressing through extended, partially folded, and fully folded states, depending on protease cleavage. The WS6 antibody inhibits viral fusion by binding to the stem helix of the S protein and preventing its refolding.

This study shows that endothelial-derived SEMA3G is down-regulated in glioblastoma. SEMA3G binds NRP2/PLXNA1 to inactivate Cdc42, freeing the E3 ligase WWP2 to ubiquitinate and degrade c-Myc, thereby impairing glioblastoma stem cell self-renewal. Restoring SEMA3G or administering recombinant protein suppresses tumor growth and prolongs survival, offering a new route to target the "undruggable" c-Myc.

An antibody-ICG conjugate is developed to trigger pyroptosis upon NIR irradiation. ICG-generated ROS rupture lysosomes, releasing cathepsin S that cleaves GSDMD, IL-1β and IL-18 independently of caspase-1. Effective in ICAM1⁺ and HER2⁺ tumors, the approach, alone or with PD-1 blockade, suppresses growth and establishes immune memory, offering a new modality to overcome apoptosis resistance.

This study reveals that tumor-associated glycosphingolipid Globo H ceramide (GHCer) binds TRAX and adenosine receptor A2AR, triggering cAMP/PKA signaling to suppress CD4+ T-cell proliferation and boost regulatory T-cell (Treg) differentiation and suppressive potency, creating an adenosine-driven positive feedback loop. Clinical specimens and animal models show positive correlation between tumor Globo H and Treg infiltration; anti-Globo H antibody reduces Treg and inhibits tumors. GHCer is proposed as a novel cancer-specific immune checkpoint target.

Testosterone delays age-related bone micro-damage in men by upregulating osteoblast-produced Tenascin-C via AR signaling; the fibrinogen C-end of TNC blocks osteoclastogenesis and bone resorption. Osteoblast-specific AR-deficient mice show severe bone loss, which is rescued by TNC-derived peptide pep2. Combining low serum Tes with elevated EV-APP offers a novel biomarker for early fracture-risk assessment.

An off-the-shelf artificial blood clot hydrogel (CCS-RSF@PRP) integrating PRP, catechol-chitosan and silk nanofibers is reported. It self-activates platelets in situ to scavenge ROS, neutralize LPS and pro-inflammatory cytokines, and repolarize macrophages from M1 to M2, thus breaking the chronic inflammatory loop in periodontitis. In a rat model, the gel markedly reduced bone loss and promoted periodontal regeneration, offering a drug- and cell-free immunomodulatory strategy with high clinical translation potential.

A cellular GWAS in Ugandans identified 77 loci linked to Mtb-induced monocyte IL1B/IL6/TNF/IFNB1 expression; α-linolenic acid metabolism genes enriched and PLA2 inhibition validated. SLC1A1 and SLIT3 variants replicated in Seattle and associated with tuberculous meningitis risk and survival in Vietnamese, revealing host genetic control of TB immunity and outcomes.