C8B Antibody

Code CSB-PA004195ESR2HU
Size US$166
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  • Western blot
    All lanes: C8B antibody at 1.28µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: Jurkat whole cell lysate
    Lane 3: Raji whole cell lysate
    Lane 4: Mouse liver tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 67 kDa
    Observed band size: 67 kDa

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA004195ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA004195ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) C8B Polyclonal antibody
Uniprot No.
Target Names
C8B
Alternative Names
C8b antibody; CO8B_HUMAN antibody; Complement component 8 beta polypeptide antibody; Complement component 8 subunit beta antibody; Complement component C8 beta chain antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Complement component C8 beta chain protein (55-350AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Gene References into Functions
  1. The binding specificity between C8 beta and C8 alpha subunits is determined by a cooperative interaction of the N-terminal thrombospondin type 1 module and the membrane attack complex/perforin domain. PMID: 12220191
  2. results indicate that the principal binding site for C9 lies within the MACPF domain of C8alpha; they also suggest this site and the binding sites for C8beta and C8gamma are distinct PMID: 16618117
Involvement in disease
Complement component 8 deficiency, 2 (C8D2)
Subcellular Location
Secreted.
Protein Families
Complement C6/C7/C8/C9 family
Database Links

HGNC: 1353

OMIM: 120960

KEGG: hsa:732

STRING: 9606.ENSP00000360281

UniGene: Hs.391835

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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