CLIP2 Antibody

Datasheet

Code	CSB-PA001692
Size	US$119
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Image	Western Blot analysis of A549 cells using CLIP-115 Polyclonal Antibody Western Blot analysis of NIH-3T3 LOVO cells using CLIP-115 Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q9UDT6

Target Names

CLIP2

Alternative Names

CAP GLY domain containing linker protein 2 antibody; CAP-Gly domain-containing linker protein 2 antibody; CLIP 115 antibody; CLIP antibody; CLIP-115 antibody; Clip2 antibody; CLIP2_HUMAN antibody; cytoplasmic linker 2 antibody; Cytoplasmic linker protein 115 antibody; Cytoplasmic linker protein 2 antibody; KIAA0291 antibody; MGC11333 antibody; restin antibody; Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2) antibody; WBSCR3 antibody; WBSCR4 antibody; Williams Beuren syndrome chromosome region 3 antibody; Williams Beuren syndrome chromosome region 4 antibody; Williams-Beuren syndrome chromosomal region 3 protein antibody; Williams-Beuren syndrome chromosomal region 4 protein antibody; WSCR3 antibody; WSCR4 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the C-terminal region of Human CLIP-115.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations.

Gene References into Functions

Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. PMID: 27729373
CLIP2 protein expression is elevated in papillary thyroid carcinomas from patients exposed to radioiodine fallout compared with a nonexposed control group. PMID: 25284583
A clear radiation dose-response relationship for the CLIP2 marker expression in post-Chernobyl papillary thyroid carcinomas PMID: 25957251
CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects PMID: 22608712
Data show that gene CLIP2 was specifically overexpressed in the exposed cases. PMID: 21606360

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Involvement in disease

CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton.

Database Links

HGNC: 2586

OMIM: 603432

KEGG: hsa:7461

STRING: 9606.ENSP00000223398

UniGene: Hs.647018

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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