CPA1 Antibody

Code CSB-PA001768
Size US$100
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  • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
  • Western Blot analysis of K562 cells using CPA1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CPA1
Alternative Names
carboxypeptidase A1 (pancreatic) antibody; Carboxypeptidase A1 antibody; Carboxypeptidase A1 precursor antibody; CBPA1_HUMAN antibody; CPA antibody; CPA1 antibody; Pancreatic carboxypeptidase A1 antibody; Procarboxypeptidase A1 pancreatic antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human CPA1.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond.
Gene References into Functions
  1. study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. PMID: 29669919
  2. Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort PMID: 28497564
  3. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
  4. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. PMID: 27358403
  5. mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity PMID: 23955596
  6. Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy PMID: 21502183
  7. A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract. PMID: 18566513

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Subcellular Location
Secreted.
Protein Families
Peptidase M14 family
Database Links

HGNC: 2296

OMIM: 114850

KEGG: hsa:1357

STRING: 9606.ENSP00000011292

UniGene: Hs.2879

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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