CPA1 Antibody

Code CSB-PA005875GA01HU
Size US$685
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Product Details

Uniprot No. P15085
Target Names CPA1
Alternative Names carboxypeptidase A1 (pancreatic) antibody; Carboxypeptidase A1 antibody; Carboxypeptidase A1 precursor antibody; CBPA1_HUMAN antibody; CPA antibody; CPA1 antibody; Pancreatic carboxypeptidase A1 antibody; Procarboxypeptidase A1 pancreatic antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human CPA1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Gene References into Functions
  1. study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. PMID: 29669919
  2. Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort PMID: 28497564
  3. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
  4. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. PMID: 27358403
  5. mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity PMID: 23955596
  6. Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy PMID: 21502183
  7. A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract. PMID: 18566513

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Subcellular Location Secreted
Protein Families Peptidase M14 family
Database Links

HGNC: 2296

OMIM: 114850

KEGG: hsa:1357

STRING: 9606.ENSP00000011292

UniGene: Hs.2879

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