CPA1 Antibody

1. study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development. PMID: 29669919
2. Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort PMID: 28497564
3. Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations. PMID: 27409067
4. Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. PMID: 27358403
5. mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity PMID: 23955596
6. Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy PMID: 21502183
7. A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract. PMID: 18566513

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HGNC: 2296

OMIM: 114850

KEGG: hsa:1357

STRING: 9606.ENSP00000011292

UniGene: Hs.2879