DUSP2 Antibody

1. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 has been reported. PMID: 28252035
2. hypoxia-induced IL-6 production in endometriotic lesions is mediated via downregulation of DUSP2, which causes aberrant activation of STAT3 signaling pathway and helps the endometriotic cells survive under the ectopic environment PMID: 28440564
3. Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer. PMID: 28652251
4. Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8, which facilitates angiogenesis and tumour metastasis. PMID: 28026024
5. Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF is involved in the epigenetic regulation of DUSP2 expression. PMID: 26833217
6. Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma. PMID: 26658840
7. identified among the key genes in circulating monocytes that were altered by exercise PMID: 26207425
8. Data show that hypoxia promotes lapatinib resistance in ERBB2-positive breast cancer cells through activation of the MEK-ERK pathway a HIF-1-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2). PMID: 25596742
9. DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis. PMID: 21984126
10. Dipyridamole reduced expression of PAC-1 and CD62p in patients with malignant lymphoma. PMID: 20723301
11. DUSP2 is a key downstream regulator of HIF-1-mediated tumor progression and chemoresistance PMID: 21490398
12. During apoptosis, p53 activates transcription of PAC1 by binding to a palindromic site in the PAC1 promoter PMID: 12673251
13. relationships between the expression levels of CD61, CD63, and PAC-1 on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation PMID: 12826159
14. variation in large granular lymphocyte leukemia PMID: 14680939
15. These results reveal a crucial role of PAC1 in E2F-1-directed apoptosis. PMID: 17471234
16. Induction of hypercortisolism in healthy volunteers was not associated with changes in the platelet activation marker PAC-1 or the number of circulating platelet-leucocyte aggregates. PMID: 18600034

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HGNC: 3068

OMIM: 603068

KEGG: hsa:1844

STRING: 9606.ENSP00000288943

UniGene: Hs.1183