ERAS Antibody

Datasheet

Code	CSB-PA009263
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q7Z444

Target Names

ERAS

Alternative Names

E ras antibody; E-Ras antibody; ecat5 antibody; Embryonic stem cell expressed Ras antibody; Embryonic stem cell-expressed Ras antibody; Eras antibody; ES cell expressed Ras antibody; GTPase ERas antibody; Ha-Ras2 antibody; HRAS2 antibody; HRASP antibody; MGC126691 antibody; MGC126693 antibody; OTTHUMP00000065857 antibody; RASE_HUMAN antibody; Small GTPase protein E Ras antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human E-Ras.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols

Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.

Gene References into Functions

N-terminal extension of E-RAS is important for E-RAS signaling activity. PMID: 25940089
Expression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphosphorylation of AKT. PMID: 25624498
After knocking down the ERas gene by siRNA, we observed that there was a significant decrease in proliferation, metastasis as well as clonality in gastric carcinoma. PMID: 23612786
Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted. PMID: 21151392
These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin. PMID: 20566745
ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma. PMID: 20811723
transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells PMID: 12774123
Studies on ERas gene expression. PMID: 16081664
rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms PMID: 18174262
High ERas is associated with the tumorigenic process of gastric carcinomas. PMID: 19528480
Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer. PMID: 19787253

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Small GTPase superfamily, Ras family

Database Links

HGNC: 5174

OMIM: 300437

KEGG: hsa:3266

STRING: 9606.ENSP00000339136

UniGene: Hs.447330

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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