ERAS Antibody

Datasheet

Code	CSB-PA699373
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA699373(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA699373(ERAS Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA699373(ERAS Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q7Z444

Target Names

ERAS

Alternative Names

E ras antibody; E-Ras antibody; ecat5 antibody; Embryonic stem cell expressed Ras antibody; Embryonic stem cell-expressed Ras antibody; Eras antibody; ES cell expressed Ras antibody; GTPase ERas antibody; Ha-Ras2 antibody; HRAS2 antibody; HRASP antibody; MGC126691 antibody; MGC126693 antibody; OTTHUMP00000065857 antibody; RASE_HUMAN antibody; Small GTPase protein E Ras antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog pseudogene antibody; v Ha ras Harvey rat sarcoma viral oncogene homolog 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human ERAS

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells.

Gene References into Functions

N-terminal extension of E-RAS is important for E-RAS signaling activity. PMID: 25940089
Expression of ERAS in human melanoma cell lines conferred resistance to PLX4720 and induced hyperphosphorylation of AKT. PMID: 25624498
After knocking down the ERas gene by siRNA, we observed that there was a significant decrease in proliferation, metastasis as well as clonality in gastric carcinoma. PMID: 23612786
Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
ERas may be a potential biomarker for gastric cancer, but advanced studies are wanted. PMID: 21151392
These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin. PMID: 20566745
ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma. PMID: 20811723
transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells PMID: 12774123
Studies on ERas gene expression. PMID: 16081664
rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms PMID: 18174262
High ERas is associated with the tumorigenic process of gastric carcinomas. PMID: 19528480
Loss of methylation in the promoter of ERas might be one of mechanisms responsible for the re-expression of an embryonic oncogene in gastric cancer. PMID: 19787253

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Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Protein Families

Small GTPase superfamily, Ras family

Database Links

HGNC: 5174

OMIM: 300437

KEGG: hsa:3266

STRING: 9606.ENSP00000339136

UniGene: Hs.447330

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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